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Mar. Drugs 2015, 13(7), 4375-4397; doi:10.3390/md13074375

A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats

1
Department of Clinical Science, University of Bergen, Bergen N-5020, Norway
2
Olympic Seafood AS, Fosnavåg N-6099, Norway
3
Department of Heart Disease, Haukeland University Hospital, Bergen N-5021, Norway
*
Author to whom correspondence should be addressed.
Academic Editor: Gilles Barnathan
Received: 28 May 2015 / Revised: 24 June 2015 / Accepted: 1 July 2015 / Published: 16 July 2015
(This article belongs to the Special Issue Marine Lipids)
View Full-Text   |   Download PDF [345 KB, uploaded 16 July 2015]   |  

Abstract

Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have health benefits. We investigated a phospholipid-protein complex (PPC) from krill that is hypothesized to influence lipid metabolism, inflammation, and redox status. Male Wistar rats were fed a control diet (2% soy oil, 8% lard, 20% casein), or diets where corresponding amounts of casein and lard were replaced with PPC at 3%, 6%, or 11% (wt %), for four weeks. Dietary supplementation with PPC resulted in significantly lower levels of plasma triacylglycerols in the 11% PPC-fed group, probably due to reduced hepatic lipogenesis. Plasma cholesterol levels were also reduced at the highest dose of PPC. In addition, the plasma and liver content of n-3 PUFAs increased while n-6 PUFAs decreased. This was associated with increased total antioxidant capacity in plasma and increased liver gene expression of mitochondrial superoxide dismutase (Sod2). Finally, a reduced plasma level of the inflammatory mediator interleukin-2 (IL-2) was detected in the PPC-fed animals. The present data show that PPC has lipid-lowering effects in rats, and may modulate risk factors related to cardiovascular disease progression. View Full-Text
Keywords: Antarctic krill; lipogenesis; plasma lipids; inflammation; antioxidant capacity; omega-3 polyunsaturated fatty acids; cholesterol; lipid lowering Antarctic krill; lipogenesis; plasma lipids; inflammation; antioxidant capacity; omega-3 polyunsaturated fatty acids; cholesterol; lipid lowering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ramsvik, M.S.; Bjørndal, B.; Bruheim, I.; Bohov, P.; Berge, R.K. A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats. Mar. Drugs 2015, 13, 4375-4397.

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