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Mar. Drugs 2015, 13(6), 3761-3775; doi:10.3390/md13063761

Sulfated Galactan from Palisada flagellifera Inhibits Toxic Effects of Lachesis muta Snake Venom

1
Department of Molecular and Cellular Biology, Federal Fluminense University, CEP 24020-141 Niterói, Rio de Janeiro, Brazil
2
Department of Biochemistry and Molecular Biology, Federal University of Paraná, CEP 81531-980 Curitiba, Paraná, Brazil
3
Laboratory of Biochemistry of Proteins from Animal Venoms, Research and Development Center, Ezequiel Dias Foundation, CEP 30510-010 Belo Horizonte, Minas Gerais, Brazil
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Valeria Costantino
Received: 8 April 2015 / Revised: 20 May 2015 / Accepted: 25 May 2015 / Published: 11 June 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)
View Full-Text   |   Download PDF [639 KB, uploaded 11 June 2015]   |  

Abstract

In Brazil, snakebites are a public health problem and accidents caused by Lachesis muta have the highest mortality index. Envenomation by L. muta is characterized by systemic (hypotension, bleeding and renal failure) and local effects (necrosis, pain and edema). The treatment to reverse the evolution of all the toxic effects is performed by injection of antivenom. However, such therapy does not effectively neutralize tissue damage or any other local effect, since in most cases victims delay seeking appropriate medical care. In this way, alternative therapies are in demand, and molecules from natural sources have been exhaustively tested. In this paper, we analyzed the inhibitory effect of a sulfated galactan obtained from the red seaweed Palisada flagellifera against some toxic activities of L. muta venom. Incubation of sulfated galactan with venom resulted in inhibition of hemolysis, coagulation, proteolysis, edema and hemorrhage. Neutralization of hemorrhage was also observed when the galactan was administered after or before the venom injection; thus mimicking a real in vivo situation. Moreover, the galactan blocked the edema caused by a phospholipase A2 isolated from the same venom. Therefore, the galactan from P. flagellifera may represent a promising tool to treat envenomation by L. muta as a coadjuvant for the conventional antivenom. View Full-Text
Keywords: sulfated galactan; Palisada flagellifera; Lachesis muta; snake venom; neutralization sulfated galactan; Palisada flagellifera; Lachesis muta; snake venom; neutralization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

da Silva, A.C.R.; Ferreira, L.G.; Duarte, M.E.R.; Noseda, M.D.; Sanchez, E.F.; Fuly, A.L. Sulfated Galactan from Palisada flagellifera Inhibits Toxic Effects of Lachesis muta Snake Venom. Mar. Drugs 2015, 13, 3761-3775.

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