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Mar. Drugs 2015, 13(5), 3231-3240; doi:10.3390/md13053231

Determination of the Chemical Structures of Tandyukisins B–D, Isolated from a Marine Sponge-Derived Fungus

Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan
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Academic Editor: Vassilios Roussis
Received: 18 March 2015 / Revised: 8 May 2015 / Accepted: 11 May 2015 / Published: 21 May 2015
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Abstract

Tandyukisins B–D (13), novel decalin derivatives, have been isolated from a strain of Trichoderma harzianum OUPS-111D-4 originally derived from the marine sponge Halichondria okadai, and their structures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques. In addition, their chemical structures were established by chemical transformation. They exhibited weak cytotoxicity, but selective growth inhibition on panel screening using 39 human cancer cell lines. View Full-Text
Keywords: decalin; Trichoderma harzianum; marine microorganism; Halichondria okadai; cytotoxicity decalin; Trichoderma harzianum; marine microorganism; Halichondria okadai; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yamada, T.; Umebayashi, Y.; Kawashima, M.; Sugiura, Y.; Kikuchi, T.; Tanaka, R. Determination of the Chemical Structures of Tandyukisins B–D, Isolated from a Marine Sponge-Derived Fungus. Mar. Drugs 2015, 13, 3231-3240.

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