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Open AccessFeature PaperCommunication
Mar. Drugs 2015, 13(1), 65-75; doi:10.3390/md13010065

Augmenting Anti-Cancer Natural Products with a Small Molecule Adjuvant

1
Biosortia Pharmaceuticals, 565 Metro Place South, Suite 300, Dublin, OH 43017, USA
2
Toxin/Natural Products Chemistry, National Ocean Service/NOAA, Hollings Marine Lab, 331 Fort Johnson Road, Charleston, SC 29412, USA
3
Department of Molecular & Structural Biochemistry, North Carolina State University, Campus Box 7622, 128 Polk Hall, Raleigh, NC 27695, USA
4
Department Chemistry, North Carolina State University, 2620 Yarbrough Drive, Box 8204, Raleigh, North Carolina 27695, USA
5
Department of Life Sciences, Texas A&M Corpus Christi, 6300 Ocean Drive, Corpus Christi, TX 78412, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Eric Blomme
Received: 1 August 2014 / Accepted: 17 December 2014 / Published: 26 December 2014
(This article belongs to the Special Issue Emerging Marine Toxins)
View Full-Text   |   Download PDF [538 KB, uploaded 24 February 2015]   |  

Abstract

Aquatic microbes produce diverse secondary metabolites with interesting biological activities. Cytotoxic metabolites have the potential to become lead compounds or drugs for cancer treatment. Many cytotoxic compounds, however, show undesirable toxicity at higher concentrations. Such undesirable activity may be reduced or eliminated by using lower doses of the cytotoxic compound in combination with another compound that modulates its activity. Here, we have examined the cytotoxicity of four microbial metabolites [ethyl N-(2-phenethyl) carbamate (NP-1), Euglenophycin, Anabaenopeptin, and Glycolipid 652] using three in vitro cell lines [human breast cancer cells (MCF-7), mouse neuroblastoma cells (N2a), and rat pituitary epithelial cells (GH4C1)]. The compounds showed variable cytotoxicity, with Euglenophycin displaying specificity for N2a cells. We have also examined the modulatory power of NP-1 on the cytotoxicity of the other three compounds and found that at a permissible concentration (125 µg/mL), NP-1 sensitized N2a and MCF-7 cells to Euglenophycin and Glycolipid 652 induced cytotoxicity. View Full-Text
Keywords: anti-cancer agents; cytotoxicity; natural products; toxins; adjuvant; small molecule anti-cancer agents; cytotoxicity; natural products; toxins; adjuvant; small molecule
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wahome, P.G.; Beauchesne, K.R.; Pedone, A.C.; Cavanagh, J.; Melander, C.; Zimba, P.; Moeller, P.D.R. Augmenting Anti-Cancer Natural Products with a Small Molecule Adjuvant. Mar. Drugs 2015, 13, 65-75.

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