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Mar. Drugs 2014, 12(12), 5719-5763; doi:10.3390/md12125719

Alternative Methods for the Detection of Emerging Marine Toxins: Biosensors, Biochemical Assays and Cell-Based Assays

IRTA, Carretera Poble Nou km 5.5, 43540 Sant Carles de la Ràpita, Spain
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Received: 5 September 2014 / Revised: 11 November 2014 / Accepted: 11 November 2014 / Published: 26 November 2014
(This article belongs to the Special Issue Emerging Marine Toxins)
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Abstract

The emergence of marine toxins in water and seafood may have a considerable impact on public health. Although the tendency in Europe is to consolidate, when possible, official reference methods based on instrumental analysis, the development of alternative or complementary methods providing functional or toxicological information may provide advantages in terms of risk identification, but also low cost, simplicity, ease of use and high-throughput analysis. This article gives an overview of the immunoassays, cell-based assays, receptor-binding assays and biosensors that have been developed for the screening and quantification of emerging marine toxins: palytoxins, ciguatoxins, cyclic imines and tetrodotoxins. Their advantages and limitations are discussed, as well as their possible integration in research and monitoring programs. View Full-Text
Keywords: palytoxin; ciguatoxin; cyclic imines; tetrodotoxin; immunoassays; cell-based assays; hemolytic assays; receptor-binding assays; biosensors palytoxin; ciguatoxin; cyclic imines; tetrodotoxin; immunoassays; cell-based assays; hemolytic assays; receptor-binding assays; biosensors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Reverté, L.; Soliño, L.; Carnicer, O.; Diogène, J.; Campàs, M. Alternative Methods for the Detection of Emerging Marine Toxins: Biosensors, Biochemical Assays and Cell-Based Assays. Mar. Drugs 2014, 12, 5719-5763.

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