Next Article in Journal
Quinone and Hydroquinone Metabolites from the Ascidians of the Genus Aplidium
Next Article in Special Issue
The Effect of Polyunsaturated Aldehydes on Skeletonema marinoi (Bacillariophyceae): The Involvement of Reactive Oxygen Species and Nitric Oxide
Previous Article in Journal
Diazaquinomycins E–G, Novel Diaza-Anthracene Analogs from a Marine-Derived Streptomyces sp.
Previous Article in Special Issue
Marennine, Promising Blue Pigments from a Widespread Haslea Diatom Species Complex
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2014, 12(6), 3587-3607; doi:10.3390/md12063587

Link between Domoic Acid Production and Cell Physiology after Exchange of Bacterial Communities between Toxic Pseudo-nitzschia multiseries and Non-Toxic Pseudo-nitzschia delicatissima

Marine Environmental Sciences Laboratory (Laboratoire des sciences de l'environnement marin, LEMAR), UMR6539, European Institute for Marine Studies (Institut Universitaire Européen de la Mer, IUEM), Rue Dumont d'Urville, Plouzané 29280, France
Author to whom correspondence should be addressed.
Received: 5 March 2014 / Revised: 4 April 2014 / Accepted: 17 April 2014 / Published: 11 June 2014
(This article belongs to the Special Issue Metabolites in Diatoms)
View Full-Text   |   Download PDF [660 KB, uploaded 24 February 2015]   |  


Bacteria are known to influence domoic acid (DA) production by Pseudo-nitzschia spp., but the link between DA production and physiology of diatoms requires more investigation. We compared a toxic P. multiseries to a non-toxic P. delicatissima, investigating links between DA production, physiological parameters, and co-occurring bacteria. Bacterial communities in cultures of both species were reduced by antibiotic treatment, and each of the diatoms was inoculated with the bacterial community of the other species. The physiology of P. delicatissima was minimally affected by the absence of bacteria or the presence of alien bacteria, and no DA was detected. P. multiseries grew faster without bacteria, did not produce a significant amount of DA, and exhibited physiological characteristics of healthy cells. When grown with alien bacteria, P. multiseries did not grow and produced more DA; the physiology of these cells was affected, with decreases in chlorophyll content and photosynthetic efficiency, an increase in esterase activity, and almost 50% mortality of the cells. The alien bacterial community had morphological and cellular characteristics very different from the original bacteria, and the number of free-living bacteria per algal cell was much higher, suggesting the involvement of bacteria in DA production. View Full-Text
Keywords: bacteria; domoic acid; physiology; Pseudo-nitzschia bacteria; domoic acid; physiology; Pseudo-nitzschia

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lelong, A.; Hégaret, H.; Soudant, P. Link between Domoic Acid Production and Cell Physiology after Exchange of Bacterial Communities between Toxic Pseudo-nitzschia multiseries and Non-Toxic Pseudo-nitzschia delicatissima. Mar. Drugs 2014, 12, 3587-3607.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top