Mar. Drugs 2014, 12(5), 2539-2589; doi:10.3390/md12052539
Review

Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases

1
, 1
, 2
 and 1,*
Received: 30 January 2014; in revised form: 10 April 2014 / Accepted: 16 April 2014 / Published: 2 May 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Abstract: Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration for marine biotechnology, particularly in drug discovery programs and biomaterials development. This review aims to summarize the potential of drugs derived from marine invertebrates in the field of neuroscience. Therefore, some examples of neuroprotective drugs and neurotoxins will be discussed. Their role in neuroscience research and development of new therapies targeting the central nervous system will be addressed, with particular focus on neuroinflammation and neurodegeneration. In addition, the neuronal growth promoted by marine drugs, as well as the recent advances in neural tissue engineering, will be highlighted.
Keywords: aragonite; conotoxins; neurodegeneration; neuroinflammation; Aβ peptide; tau hyperphosphorylation; protein kinases; receptors; voltage-dependent ion channels; cyclooxygenases
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Grosso, C.; Valentão, P.; Ferreres, F.; Andrade, P.B. Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases. Mar. Drugs 2014, 12, 2539-2589.

AMA Style

Grosso C, Valentão P, Ferreres F, Andrade PB. Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases. Marine Drugs. 2014; 12(5):2539-2589.

Chicago/Turabian Style

Grosso, Clara; Valentão, Patrícia; Ferreres, Federico; Andrade, Paula B. 2014. "Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases." Mar. Drugs 12, no. 5: 2539-2589.


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