Next Article in Journal
Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases
Previous Article in Journal
Four New Jacaranone Analogs from the Fruits of a Beibu Gulf Mangrove Avicennia marina
Mar. Drugs 2014, 12(5), 2526-2538; doi:10.3390/md12052526
Article

New Benzoxazine Secondary Metabolites from an Arctic Actinomycete

1
,
2
,
1
,
1
,
1
,
1
,
2
,
1
,
3
 and
1,*
Received: 12 March 2014 / Revised: 2 April 2014 / Accepted: 15 April 2014 / Published: 30 April 2014
View Full-Text   |   Download PDF [813 KB, uploaded 24 February 2015]   |   Browse Figures

Abstract

Two new secondary metabolites, arcticoside (1) and C-1027 chromophore-V (2), were isolated along with C-1027 chromophore-III and fijiolides A and B (35) from a culture of an Arctic marine actinomycete Streptomyces strain. The chemical structures of 1 and 2 were elucidated through NMR, mass, UV, and IR spectroscopy. The hexose moieties in 1 were determined to be d-glucose from a combination of acid hydrolysis, derivatization, and gas chromatographic analyses. Arcticoside (1) and C-1027 chromophore-V (2), which have a benzoxazine ring, inhibited Candida albicans isocitrate lyase. Chromophore-V (2) exhibited significant cytotoxicity against breast carcinoma MDA-MB231 cells and colorectal carcinoma cells (line HCT-116), with IC50 values of 0.9 and 2.7 μM, respectively.
Keywords: Arctic; marine actinomycete; secondary metabolite; benzoxazine; C-1027; fijiolides; disaccharide; isocitrate lyase Arctic; marine actinomycete; secondary metabolite; benzoxazine; C-1027; fijiolides; disaccharide; isocitrate lyase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplement

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Moon, K.; Ahn, C.-H.; Shin, Y.; Won, T.H.; Ko, K.; Lee, S.K.; Oh, K.-B.; Shin, J.; Nam, S.-I.; Oh, D.-C. New Benzoxazine Secondary Metabolites from an Arctic Actinomycete. Mar. Drugs 2014, 12, 2526-2538.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert