New Benzoxazine Secondary Metabolites from an Arctic Actinomycete
AbstractTwo new secondary metabolites, arcticoside (1) and C-1027 chromophore-V (2), were isolated along with C-1027 chromophore-III and fijiolides A and B (3–5) from a culture of an Arctic marine actinomycete Streptomyces strain. The chemical structures of 1 and 2 were elucidated through NMR, mass, UV, and IR spectroscopy. The hexose moieties in 1 were determined to be d-glucose from a combination of acid hydrolysis, derivatization, and gas chromatographic analyses. Arcticoside (1) and C-1027 chromophore-V (2), which have a benzoxazine ring, inhibited Candida albicans isocitrate lyase. Chromophore-V (2) exhibited significant cytotoxicity against breast carcinoma MDA-MB231 cells and colorectal carcinoma cells (line HCT-116), with IC50 values of 0.9 and 2.7 μM, respectively.
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Moon, K.; Ahn, C.-H.; Shin, Y.; Won, T.H.; Ko, K.; Lee, S.K.; Oh, K.-B.; Shin, J.; Nam, S.-I.; Oh, D.-C. New Benzoxazine Secondary Metabolites from an Arctic Actinomycete. Mar. Drugs 2014, 12, 2526-2538.
Moon K, Ahn C-H, Shin Y, Won TH, Ko K, Lee SK, Oh K-B, Shin J, Nam S-I, Oh D-C. New Benzoxazine Secondary Metabolites from an Arctic Actinomycete. Marine Drugs. 2014; 12(5):2526-2538.Chicago/Turabian Style
Moon, Kyuho; Ahn, Chan-Hong; Shin, Yoonho; Won, Tae H.; Ko, Keebeom; Lee, Sang K.; Oh, Ki-Bong; Shin, Jongheon; Nam, Seung-Il; Oh, Dong-Chan. 2014. "New Benzoxazine Secondary Metabolites from an Arctic Actinomycete." Mar. Drugs 12, no. 5: 2526-2538.