Mar. Drugs 2014, 12(4), 2079-2088; doi:10.3390/md12042079
Communication

Phenolic Polyketides from the Co-Cultivation of Marine-Derived Penicillium sp. WC-29-5 and Streptomyces fradiae 007

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Received: 15 January 2014; in revised form: 24 February 2014 / Accepted: 21 March 2014 / Published: 4 April 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Penicillium sp. WC-29-5 was co-cultured with Streptomyces fradiae 007 to produce five natural products (13, 4a and 4b) that were isolated and characterized by spectroscopic analysis. Interestingly, these compounds were found to be different from those produced in discrete fungal and bacterial controls. Among these compounds, the absolute configurations of compounds 4a and 4b were determined for the first time by X-ray single crystal diffraction experiments and electronic circular dichroism (ECD) calculations. An evaluation of the cytotoxic activities of these compounds revealed that 4b was moderately cytotoxic towards HL-60 and H1975 tumor cells with IC50 values of 3.73 and 5.73 µM, respectively, whereas compound 4a was only moderately cytotoxic towards H1975 cells with an IC50 value of 3.97 µM.
Keywords: Penicillium sp.; Streptomyces fradiae; co-cultivation; secondary metabolites; cytotoxicity
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MDPI and ACS Style

Wang, Y.; Wang, L.; Zhuang, Y.; Kong, F.; Zhang, C.; Zhu, W. Phenolic Polyketides from the Co-Cultivation of Marine-Derived Penicillium sp. WC-29-5 and Streptomyces fradiae 007. Mar. Drugs 2014, 12, 2079-2088.

AMA Style

Wang Y, Wang L, Zhuang Y, Kong F, Zhang C, Zhu W. Phenolic Polyketides from the Co-Cultivation of Marine-Derived Penicillium sp. WC-29-5 and Streptomyces fradiae 007. Marine Drugs. 2014; 12(4):2079-2088.

Chicago/Turabian Style

Wang, Yi; Wang, Liping; Zhuang, Yibin; Kong, Fandong; Zhang, Cuixian; Zhu, Weiming. 2014. "Phenolic Polyketides from the Co-Cultivation of Marine-Derived Penicillium sp. WC-29-5 and Streptomyces fradiae 007." Mar. Drugs 12, no. 4: 2079-2088.


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