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Mar. Drugs 2014, 12(12), 6236-6253; doi:10.3390/md12126236

Design of Chitosan and Its Water Soluble Derivatives-Based Drug Carriers with Polyelectrolyte Complexes

1
Integrated Biotechnology Laboratory, School of Life Science, Anhui University, Hefei 230601, China
2
Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China
3
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China
*
Author to whom correspondence should be addressed.
Received: 9 October 2014 / Revised: 11 December 2014 / Accepted: 12 December 2014 / Published: 19 December 2014
(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan)
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Abstract

Chitosan, the cationic polysaccharide derived from the natural polysaccharide chitin, has been studied as a biomaterial for more than two decades. As a polycationic polymer with favorable properties, it has been widely used to form polyelectrolyte complexes with polyanions for various applications in drug delivery fields. In recent years, a growing number of studies have been focused on the preparation of polyelectrolyte complexes based on chitosan and its water soluble derivatives. They have been considered well-suited as biomaterials for a number of vital drug carriers with targeted/controlled release profiles, e.g., films, capsules, microcapsules. In this work, an overview highlights not only the favorable properties of chitosan and its water soluble derivatives but also the good performance of the polyelectrolyte complexes produced based on chitosan. Their various types of applications as drug carriers are reviewed in detail. View Full-Text
Keywords: chitosan; water soluble chitosan; drug carriers; polyelectrolyte complexes; targeted/controlled release chitosan; water soluble chitosan; drug carriers; polyelectrolyte complexes; targeted/controlled release
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wu, Q.-X.; Lin, D.-Q.; Yao, S.-J. Design of Chitosan and Its Water Soluble Derivatives-Based Drug Carriers with Polyelectrolyte Complexes. Mar. Drugs 2014, 12, 6236-6253.

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