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Mar. Drugs 2014, 12(12), 6213-6235; doi:10.3390/md12126213

An Update on 2,5-Diketopiperazines from Marine Organisms

1
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
2
Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK
3
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China
4
Department of Cell Biology, Jinan University, Guangzhou 510632, China
5
Life Science & Technology School, Lingnan Normal University, Zhanjiang 52048, China
6
Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China
*
Author to whom correspondence should be addressed.
Received: 14 September 2014 / Revised: 5 December 2014 / Accepted: 9 December 2014 / Published: 19 December 2014

Abstract

2,5-Diketopiperazines (2,5-DKPs) are an important category of structurally diverse cyclic dipeptides with prominent biological properties. These 2,5-DKPs have been obtained from a variety of natural resources, including marine organisms. Because of the increasing numbers and biological importance of these compounds, this review covers 90 marine originated 2,5-DKPs that were reported from 2009 to the first half-year of 2014. The review will focus on the structure characterizations, biological properties and proposed biosynthetic processes of these compounds. View Full-Text
Keywords: 2,5-diketopiperazine; marine organism; biosynthetic processes; biological activity 2,5-diketopiperazine; marine organism; biosynthetic processes; biological activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Huang, R.-M.; Yi, X.-X.; Zhou, Y.; Su, X.; Peng, Y.; Gao, C.-H. An Update on 2,5-Diketopiperazines from Marine Organisms. Mar. Drugs 2014, 12, 6213-6235.

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