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Mar. Drugs 2014, 12(12), 6038-6057; doi:10.3390/md12126038

Glycol Chitosan-Based Fluorescent Theranostic Nanoagents for Cancer Therapy

1
Western Seoul Center, Korea Basic Science Institute, Seoul 120-140, Korea
2
Division of Bio-imaging, Chuncheon Center, Korea Basic Science Institute, Gangwon-do 200-701, Korea
3
Biomedical Research Center, Korea Institute of Science and Technology, Seoul 136-791, Korea
4
Institute of Cell & Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 9 October 2014 / Revised: 27 November 2014 / Accepted: 27 November 2014 / Published: 17 December 2014
(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan)
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Abstract

Theranostics is an integrated nanosystem that combines therapeutics with diagnostics in attempt to develop new personalized treatments with enhanced therapeutic efficacy and safety. As a promising therapeutic paradigm with cutting-edge technologies, theranostic agents are able to simultaneously deliver therapeutic drugs and diagnostic imaging agents and also monitor the response to therapy. Polymeric nanosystems have been intensively explored for biomedical applications to diagnose and treat various cancers. In recent years, glycol chitosan-based nanoagents have been developed as dual-purpose materials for simultaneous diagnosis and therapy. They have shown great potential in cancer therapies, such as chemotherapeutics and nucleic acid and photodynamic therapies. In this review, we summarize the recent progress and potential applications of glycol chitosan-based fluorescent theranostic nanoagents for cancer treatments and discuss their possible underlying mechanisms. View Full-Text
Keywords: glycol chitosan; theranostics; nanosystem; fluorescence; cancer glycol chitosan; theranostics; nanosystem; fluorescence; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rhee, J.-K.; Park, O.K.; Lee, A.; Yang, D.H.; Park, K. Glycol Chitosan-Based Fluorescent Theranostic Nanoagents for Cancer Therapy. Mar. Drugs 2014, 12, 6038-6057.

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