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Mar. Drugs 2014, 12(12), 5801-5816; doi:10.3390/md12125801

The Influence of 1-Butanol and Trisodium Citrate Ion on Morphology and Chemical Properties of Chitosan-Based Microcapsules during Rigidification by Alkali Treatment

1
University of Lille Nord de France, F-59000 Lille, France
2
ENSAIT/GEMTEX, F-59100 Roubaix, France
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 9 October 2014 / Revised: 17 November 2014 / Accepted: 19 November 2014 / Published: 2 December 2014
(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan)
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Abstract

Linseed oil which has various biomedical applications was encapsulated by chitosan (Chi)-based microcapsules in the development of a suitable carrier. Oil droplets formed in oil-in-water emulsion using sodium dodecyl sulfate (SDS) as emulsifier was stabilized by Chi, and microcapsules with multilayers were formed by alternate additions of SDS and Chi solutions in an emulsion through electrostatic interaction. No chemical cross-linker was used in the study and the multilayer shell membrane was formed by ionic gelation using Chi and SDS. The rigidification of the shell membrane of microcapsules was achieved by alkali treatment in the presence of a small amount of 1-butanol to reduce aggregation. A trisodium citrate solution was used to stabilize the charge of microcapsules by ionic cross-linking. Effects of butanol during alkali treatment and citrate in post alkali treatment were monitored in terms of morphology and the chemical properties of microcapsules. Various characterization techniques revealed that the aggregation was decreased and surface roughness was increased with layer formation. View Full-Text
Keywords: microcapsules; linseed oil; chitosan; 1-butanol; trisodium citrate; oil-in-water emulsion; alkali treatment microcapsules; linseed oil; chitosan; 1-butanol; trisodium citrate; oil-in-water emulsion; alkali treatment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chatterjee, S.; Salaün, F.; Campagne, C. The Influence of 1-Butanol and Trisodium Citrate Ion on Morphology and Chemical Properties of Chitosan-Based Microcapsules during Rigidification by Alkali Treatment. Mar. Drugs 2014, 12, 5801-5816.

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