Two New Lyngbyatoxin Derivatives from the Cyanobacterium, Moorea producens
AbstractThe toxin-producing cyanobacterium, Moorea producens, is a known causative organism of food poisoning and seaweed dermatitis (also known as “swimmer’s itch”). Two new toxic compounds were isolated and structurally elucidated from an ethyl acetate extract of M. producens collected from Hawaii. Analyses of HR-ESI-MS and NMR spectroscopies, as well as optical rotations and CD spectra indicated two new lyngbyatoxin derivatives, 2-oxo-3(R)-hydroxy-lyngbyatoxin A (1) and 2-oxo-3(R)-hydroxy-13-N-desmethyl-lyngbyatoxin A (2). The cytotoxicity and lethal activities of 1 and 2 were approximately 10- to 150-times less potent than lyngbyatoxin A. Additionally, the binding activities of 1 and 2 possessed 10,000-times lower affinity for the protein kinase Cδ (PKCδ)-C1B peptide when compared to lyngbyatoxin A. These findings suggest that these new lyngbyatoxin derivatives may mediate their acute toxicities through a non-PKC activation pathway. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 2219 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Jiang, W.; Tan, S.; Hanaki, Y.; Irie, K.; Uchida, H.; Watanabe, R.; Suzuki, T.; Sakamoto, B.; Kamio, M.; Nagai, H. Two New Lyngbyatoxin Derivatives from the Cyanobacterium, Moorea producens. Mar. Drugs 2014, 12, 5788-5800.
Jiang W, Tan S, Hanaki Y, Irie K, Uchida H, Watanabe R, Suzuki T, Sakamoto B, Kamio M, Nagai H. Two New Lyngbyatoxin Derivatives from the Cyanobacterium, Moorea producens. Marine Drugs. 2014; 12(12):5788-5800.Chicago/Turabian Style
Jiang, Weina; Tan, Satoshi; Hanaki, Yusuke; Irie, Kazuhiro; Uchida, Hajime; Watanabe, Ryuichi; Suzuki, Toshiyuki; Sakamoto, Bryan; Kamio, Michiya; Nagai, Hiroshi. 2014. "Two New Lyngbyatoxin Derivatives from the Cyanobacterium, Moorea producens." Mar. Drugs 12, no. 12: 5788-5800.