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Mar. Drugs 2014, 12(11), 5396-5407; doi:10.3390/md12115396

Resolvin D1, a Metabolite of Omega-3 Polyunsaturated Fatty Acid, Decreases Post-Myocardial Infarct Depression

1
Centre de biomédecine, Hôpital du Sacré-Cœur de Montréal, 5400 boul. Gouin Ouest, Montréal, PQ H4J 1C5, Canada
2
Université de Montréal, C.P. 6128 Succursale Centre-ville, Montréal, PQ H3C 3J7, Canada
3
Université de Montréal, C.P. 6128 Succursale Centre-ville, Montréal, PQ H3C 3J7, Canada
*
Author to whom correspondence should be addressed.
Received: 24 September 2014 / Revised: 30 October 2014 / Accepted: 4 November 2014 / Published: 13 November 2014
(This article belongs to the Special Issue Marine Functional Food Products - Cardiovascular Diseases)
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Abstract

We hypothesized that inflammation induced by myocardial ischemia plays a central role in depression-like behavior after myocardial infarction (MI). Several experimental approaches that reduce inflammation also result in attenuation of depressive symptoms. We have demonstrated that Resolvin D1 (RvD1), a metabolite of omega-3 polyunsaturated fatty acids (PUFA) derived from docosahexaenoic acid, diminishes infarct size and neutrophil accumulation in the ischemic myocardium. The aim of this study is to determine if a single RvD1 injection could alleviate depressive symptoms in a rat model of MI. MI was induced in rats by occlusion of the left anterior descending coronary artery for 40 min. Five minutes before ischemia or after reperfusion, 0.1 μg of RvD1 or vehicle was injected in the left ventricle cavity. Fourteen days after MI, behavioral tests (forced swim test and socialization) were conducted to evaluate depression-like symptoms. RvD1 reduced infarct size in the treated vs. the vehicle group. Animals receiving RvD1 also showed better performance in the forced swim and social interaction tests vs. vehicle controls. These results indicate that a single RvD1 dose, given 5 min before occlusion or 5 min after the onset of reperfusion, decreases infarct size and attenuates depression-like symptoms. View Full-Text
Keywords: Omega-3; Resolvin D1; myocardial infarction; apoptosis; limbic system; depression Omega-3; Resolvin D1; myocardial infarction; apoptosis; limbic system; depression
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gilbert, K.; Bernier, J.; Godbout, R.; Rousseau, G. Resolvin D1, a Metabolite of Omega-3 Polyunsaturated Fatty Acid, Decreases Post-Myocardial Infarct Depression. Mar. Drugs 2014, 12, 5396-5407.

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