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Mar. Drugs 2014, 12(11), 5408-5424; doi:10.3390/md12115408

Reactive Oxygen Species and Autophagy Modulation in Non-Marine Drugs and Marine Drugs

1
Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore 54000, Pakistan
2
Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
3
Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
4
Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan
5
Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
6
Department of Radiation Oncology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan
7
Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
8
Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan
9
Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
10
Research Center of Environmental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
*
Author to whom correspondence should be addressed.
Received: 4 September 2014 / Revised: 6 November 2014 / Accepted: 7 November 2014 / Published: 13 November 2014
(This article belongs to the Collection Marine Compounds and Cancer)
View Full-Text   |   Download PDF [396 KB, uploaded 24 February 2015]

Abstract

It is becoming more understandable that an existing challenge for translational research is the development of pharmaceuticals that appropriately target reactive oxygen species (ROS)-mediated molecular networks in cancer cells. In line with this approach, there is an overwhelmingly increasing list of many non-marine drugs and marine drugs reported to be involved in inhibiting and suppressing cancer progression through ROS-mediated cell death. In this review, we describe the strategy of oxidative stress-based therapy and connect the ROS modulating effect to the regulation of apoptosis and autophagy. Finally, we focus on exploring the function and mechanism of cancer therapy by the autophagy modulators including inhibitors and inducers from non-marine drugs and marine drugs. View Full-Text
Keywords: reactive oxygen species; autophagy; marine drugs; autophagy inhibitors; autophagy inducers reactive oxygen species; autophagy; marine drugs; autophagy inhibitors; autophagy inducers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Farooqi, A.A.; Fayyaz, S.; Hou, M.-F.; Li, K.-T.; Tang, J.-Y.; Chang, H.-W. Reactive Oxygen Species and Autophagy Modulation in Non-Marine Drugs and Marine Drugs. Mar. Drugs 2014, 12, 5408-5424.

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