Open AccessThis article is
- freely available
Antioxidant and Anti-Inflammatory Activities of Barettin
MabCent-SFI, University of Tromsø, Breivika N-9037 Tromsø, Norway
Marbio, University of Tromsø, Breivika N-9037 Tromsø, Norway
Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, N-9037 Tromsø, Norway
Faculty of Biosciences, Fisheries and Economics, University of Tromsø, N-9037 Tromsø, Norway
Department of Chemistry, University of Tromsø, N-9037 Tromsø, Norway
* Author to whom correspondence should be addressed.
Received: 18 June 2013; in revised form: 8 July 2013 / Accepted: 17 July 2013 / Published: 22 July 2013
Abstract: In this paper, we present novel bioactivity for barettin isolated from the marine sponge Geodia barretti. We found that barettin showed strong antioxidant activity in biochemical assays as well as in a lipid peroxidation cell assay. A de-brominated synthetic analogue of barettin did not show the same activity in the antioxidant cell assay, indicating that bromine is important for cellular activity. Barettin was also able to inhibit the secretion of the inflammatory cytokines IL-1β and TNFα from LPS-stimulated THP-1 cells. This combination of anti-inflammatory and antioxidant activities could indicate that barettin has an atheroprotective effect and may therefore be an interesting product to prevent development of atherosclerosis.
Keywords: anti-inflammatory; antioxidant; barettin; natural product
Citations to this Article
Cite This Article
MDPI and ACS Style
Lind, K.F.; Hansen, E.; Østerud, B.; Eilertsen, K.-E.; Bayer, A.; Engqvist, M.; Leszczak, K.; Jørgensen, T.Ø.; Andersen, J.H. Antioxidant and Anti-Inflammatory Activities of Barettin. Mar. Drugs 2013, 11, 2655-2666.
Lind KF, Hansen E, Østerud B, Eilertsen K-E, Bayer A, Engqvist M, Leszczak K, Jørgensen TØ, Andersen JH. Antioxidant and Anti-Inflammatory Activities of Barettin. Marine Drugs. 2013; 11(7):2655-2666.
Lind, Karianne F.; Hansen, Espen; Østerud, Bjarne; Eilertsen, Karl-Erik; Bayer, Annette; Engqvist, Magnus; Leszczak, Kinga; Jørgensen, Trond Ø.; Andersen, Jeanette H. 2013. "Antioxidant and Anti-Inflammatory Activities of Barettin." Mar. Drugs 11, no. 7: 2655-2666.