Mar. Drugs 2013, 11(6), 1866-1877; doi:10.3390/md11061866

Self-Association of Okadaic Acid: Structural and Pharmacological Significance

1,2email, 1,3email, 4email, 1,3,* email and 1,5,* email
Received: 25 March 2013; in revised form: 6 May 2013 / Accepted: 7 May 2013 / Published: 29 May 2013
(This article belongs to the Special Issue Okadaic Acid and Dinophysis Toxins)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Okadaic acid (OA) has been an invaluable pharmacological tool in the study of cellular signaling. The great affinity of this polyether for its targets together with its high specificity to inhibit certain protein phosphatases enables the differential study of these proteins. Crystallographic structures of protein phosphatases in complex with OA show a 1:1 protein to toxin ratio. Nevertheless, it has been found that OA is able to self-associate under certain conditions although very little is known about the importance of this phenomenon. Here we review the available knowledge on the latter topic and we report on the existence of an unusual self-associated tetrameric form. The structure of these oligomers is proposed based on spectroscopic data and molecular modeling calculations.
Keywords: okadaic acid; protein phosphatase; nuclear magnetic resonance; scanning tunneling microscopy
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MDPI and ACS Style

Cruz, P.G.; Norte, M.; Creus, A.H.; Fernández, J.J.; Daranas, A.H. Self-Association of Okadaic Acid: Structural and Pharmacological Significance. Mar. Drugs 2013, 11, 1866-1877.

AMA Style

Cruz PG, Norte M, Creus AH, Fernández JJ, Daranas AH. Self-Association of Okadaic Acid: Structural and Pharmacological Significance. Marine Drugs. 2013; 11(6):1866-1877.

Chicago/Turabian Style

Cruz, Patricia G.; Norte, Manuel; Creus, Alberto H.; Fernández, José J.; Daranas, Antonio H. 2013. "Self-Association of Okadaic Acid: Structural and Pharmacological Significance." Mar. Drugs 11, no. 6: 1866-1877.

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