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Mar. Drugs 2013, 11(5), 1693-1717; doi:10.3390/md11051693
Review

“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin

1,2,* , 1,2,*  and 1,2,3,4,*
Received: 12 March 2013; in revised form: 7 April 2013 / Accepted: 23 April 2013 / Published: 21 May 2013
(This article belongs to the Special Issue Marine Peptides and Their Mimetics)
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Abstract: Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as “head-to-side-chain” cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond between the C-terminus and a β-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. This structural pattern, the presence of unique and complex residues, and relevant bioactivity are the main features shared by all the members of this new class of depsipeptides, which are reviewed herein.
Keywords: natural products; peptides; polyketides; therapeutic agents natural products; peptides; polyketides; therapeutic agents
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pelay-Gimeno, M.; Tulla-Puche, J.; Albericio, F. “Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin. Mar. Drugs 2013, 11, 1693-1717.

AMA Style

Pelay-Gimeno M, Tulla-Puche J, Albericio F. “Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin. Marine Drugs. 2013; 11(5):1693-1717.

Chicago/Turabian Style

Pelay-Gimeno, Marta; Tulla-Puche, Judit; Albericio, Fernando. 2013. "“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin." Mar. Drugs 11, no. 5: 1693-1717.



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