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“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin
Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, Barcelona 08028, Spain
CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Baldiri Reixac 10, Barcelona 08028, Spain
Department of Organic Chemistry, University of Barcelona, Martí i Franqués 1-11, Barcelona 08028, Spain
School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, South Africa
* Authors to whom correspondence should be addressed.
Received: 12 March 2013; in revised form: 7 April 2013 / Accepted: 23 April 2013 / Published: 21 May 2013
Abstract: Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as “head-to-side-chain” cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond between the C-terminus and a β-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. This structural pattern, the presence of unique and complex residues, and relevant bioactivity are the main features shared by all the members of this new class of depsipeptides, which are reviewed herein.
Keywords: natural products; peptides; polyketides; therapeutic agents
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Pelay-Gimeno, M.; Tulla-Puche, J.; Albericio, F. “Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin. Mar. Drugs 2013, 11, 1693-1717.
Pelay-Gimeno M, Tulla-Puche J, Albericio F. “Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin. Marine Drugs. 2013; 11(5):1693-1717.
Pelay-Gimeno, Marta; Tulla-Puche, Judit; Albericio, Fernando. 2013. "“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin." Mar. Drugs 11, no. 5: 1693-1717.