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“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin
AbstractSince the late 1980s, a large number of depsipeptides that contain a new topography, referred to as “head-to-side-chain” cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond between the C-terminus and a β-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. This structural pattern, the presence of unique and complex residues, and relevant bioactivity are the main features shared by all the members of this new class of depsipeptides, which are reviewed herein.
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Pelay-Gimeno, M.; Tulla-Puche, J.; Albericio, F. “Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin. Mar. Drugs 2013, 11, 1693-1717.View more citation formats
Pelay-Gimeno M, Tulla-Puche J, Albericio F. “Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin. Marine Drugs. 2013; 11(5):1693-1717.Chicago/Turabian Style
Pelay-Gimeno, Marta; Tulla-Puche, Judit; Albericio, Fernando. 2013. "“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin." Mar. Drugs 11, no. 5: 1693-1717.