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“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin
Mar. Drugs 2013, 11(5), 1718-1727; doi:10.3390/md11051718
Article

Polyketides from a Marine-Derived Fungus Xylariaceae sp.

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Received: 19 March 2013 / Revised: 22 April 2013 / Accepted: 25 April 2013 / Published: 21 May 2013
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Abstract

Eighteen polyketides (118) including six citrinin derivatives, two phenol derivatives, one cyclopentenone, two naphthol derivatives, and seven tetralone derivatives were isolated from the culture broth of a marine-derived fungal strain Xylariaceae sp. SCSGAF0086. Five of these compounds (1, 2, 8, 9, and 10) were new, and their structures were determined by spectroscopic methods. Compounds 4, 6, 7, and 17 showed enzyme-inhibitory activities towards several tested enzymes, and 6 and 7 showed strong antifouling activity against Bugula neritina larvae settlement. This is the first time that the antifouling and enzyme-inhibitory activities of these compounds has been reported.
Keywords: Xylariaceae sp.; polyketide; enzyme-inhibitory activity; antifouling activity Xylariaceae sp.; polyketide; enzyme-inhibitory activity; antifouling activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nong, X.-H.; Zheng, Z.-H.; Zhang, X.-Y.; Lu, X.-H.; Qi, S.-H. Polyketides from a Marine-Derived Fungus Xylariaceae sp.. Mar. Drugs 2013, 11, 1718-1727.

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