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Mar. Drugs 2013, 11(5), 1534-1552; doi:10.3390/md11051534
Article

Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde

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1 State Key Laboratory of Rice Biology, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China 2 State Key Laboratory Breeding Base for Zhejiang Sustainable Plant Pest and Disease Control, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China 3 College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, China 4 Institute of Digital Agriculture, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China 5 Research and Development Center of Biorational Pesticides, Northwest A & F University, Yangling, Shaanxi 712100, China 6 State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou 310006, China
* Authors to whom correspondence should be addressed.
Received: 18 February 2013 / Revised: 17 April 2013 / Accepted: 26 April 2013 / Published: 13 May 2013
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Abstract

This present study deals with synthesis, characterization and antibacterial activity of cross-linked chitosan-glutaraldehyde. Results from this study indicated that cross-linked chitosan-glutaraldehyde markedly inhibited the growth of antibiotic-resistant Burkholderia cepacia complex regardless of bacterial species and incubation time while bacterial growth was unaffected by solid chitosan. Furthermore, high temperature treated cross-linked chitosan-glutaraldehyde showed strong antibacterial activity against the selected strain 0901 although the inhibitory effects varied with different temperatures. In addition, physical-chemical and structural characterization revealed that the cross-linking of chitosan with glutaraldehyde resulted in a rougher surface morphology, a characteristic Fourier transform infrared (FTIR) band at 1559 cm−1, a specific X-ray diffraction peak centered at 2θ = 15°, a lower contents of carbon, hydrogen and nitrogen, and a higher stability of glucose units compared to chitosan based on scanning electron microscopic observation, FTIR spectra, X-ray diffraction pattern, as well as elemental and thermo gravimetric analysis. Overall, this study indicated that cross-linked chitosan-glutaraldehyde is promising to be developed as a new antibacterial drug.
Keywords: antibacterial activity; characterization; chitosan; cross-link; glutaraldehyde antibacterial activity; characterization; chitosan; cross-link; glutaraldehyde
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, B.; Shan, C.-L.; Zhou, Q.; Fang, Y.; Wang, Y.-L.; Xu, F.; Han, L.-R.; Ibrahim, M.; Guo, L.-B.; Xie, G.-L.; Sun, G.-C. Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde. Mar. Drugs 2013, 11, 1534-1552.

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