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Mar. Drugs 2013, 11(3), 800-816; doi:10.3390/md11030800
Article

Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550

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Received: 18 December 2012 / Revised: 17 January 2013 / Accepted: 6 February 2013 / Published: 12 March 2013
(This article belongs to the Special Issue Bioactive Compounds from Marine Fungi)
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Abstract

Microbial studies of the Mediterranean sponge Tethya aurantium led to the isolation of the fungus Bartalinia robillardoides strain LF550. The strain produced a number of secondary metabolites belonging to the chloroazaphilones. This is the first report on the isolation of chloroazaphilones of a fungal strain belonging to the genus Bartalinia. Besides some known compounds (helicusin A (1) and deacetylsclerotiorin (2)), three new chloroazaphilones (helicusin E (3); isochromophilone X (4) and isochromophilone XI (5)) and one new pentaketide (bartanolide (6)) were isolated. The structure elucidations were based on spectroscopic analyses. All isolated compounds revealed different biological activity spectra against a test panel of four bacteria: three fungi; two tumor cell lines and two enzymes.
Keywords: marine natural product; azaphilone; pentaketide; Bartalinia robillardoides; Tethya aurantium marine natural product; azaphilone; pentaketide; Bartalinia robillardoides; Tethya aurantium
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Jansen, N.; Ohlendorf, B.; Erhard, A.; Bruhn, T.; Bringmann, G.; Imhoff, J.F. Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550. Mar. Drugs 2013, 11, 800-816.

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