Mar. Drugs 2013, 11(3), 800-816; doi:10.3390/md11030800
Article

Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550

1 Kiel Centre for Marine Natural Products at the Helmholtz Centre for Ocean Research (GEOMAR), Kiel 24106, Germany 2 Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany
* Author to whom correspondence should be addressed.
Received: 18 December 2012; in revised form: 17 January 2013 / Accepted: 6 February 2013 / Published: 12 March 2013
(This article belongs to the Special Issue Bioactive Compounds from Marine Fungi)
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Abstract: Microbial studies of the Mediterranean sponge Tethya aurantium led to the isolation of the fungus Bartalinia robillardoides strain LF550. The strain produced a number of secondary metabolites belonging to the chloroazaphilones. This is the first report on the isolation of chloroazaphilones of a fungal strain belonging to the genus Bartalinia. Besides some known compounds (helicusin A (1) and deacetylsclerotiorin (2)), three new chloroazaphilones (helicusin E (3); isochromophilone X (4) and isochromophilone XI (5)) and one new pentaketide (bartanolide (6)) were isolated. The structure elucidations were based on spectroscopic analyses. All isolated compounds revealed different biological activity spectra against a test panel of four bacteria: three fungi; two tumor cell lines and two enzymes.
Keywords: marine natural product; azaphilone; pentaketide; Bartalinia robillardoides; Tethya aurantium

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MDPI and ACS Style

Jansen, N.; Ohlendorf, B.; Erhard, A.; Bruhn, T.; Bringmann, G.; Imhoff, J.F. Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550. Mar. Drugs 2013, 11, 800-816.

AMA Style

Jansen N, Ohlendorf B, Erhard A, Bruhn T, Bringmann G, Imhoff JF. Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550. Marine Drugs. 2013; 11(3):800-816.

Chicago/Turabian Style

Jansen, Nils; Ohlendorf, Birgit; Erhard, Arlette; Bruhn, Torsten; Bringmann, Gerhard; Imhoff, Johannes F. 2013. "Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550." Mar. Drugs 11, no. 3: 800-816.

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