Mar. Drugs 2013, 11(3), 788-799; doi:10.3390/md11030788
Article

Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

Received: 9 January 2013; in revised form: 6 February 2013 / Accepted: 19 February 2013 / Published: 12 March 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Five new eunicellin-based diterpenoids, krempfielins E–I (15) and seven known compounds (612) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. Metabolites 5, 6, 10 and 12 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 6 and 10 could potently inhibit the accumulation of the pro-inflammatory iNOS protein, and 6 and 12 could significantly reduce the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
Keywords: eunicellin-based diterpenoids; Cladiella krempfi; cytotoxicity; anti-inflammatory agents
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MDPI and ACS Style

Tai, C.-J.; Su, J.-H.; Huang, C.-Y.; Huang, M.-S.; Wen, Z.-H.; Dai, C.-F.; Sheu, J.-H. Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi. Mar. Drugs 2013, 11, 788-799.

AMA Style

Tai C-J, Su J-H, Huang C-Y, Huang M-S, Wen Z-H, Dai C-F, Sheu J-H. Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi. Marine Drugs. 2013; 11(3):788-799.

Chicago/Turabian Style

Tai, Chi-Jen; Su, Jui-Hsin; Huang, Chiung-Yao; Huang, Ming-Shyan; Wen, Zhi-Hong; Dai, Chang-Feng; Sheu, Jyh-Horng. 2013. "Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi." Mar. Drugs 11, no. 3: 788-799.

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