Mar. Drugs 2013, 11(3), 788-799; doi:10.3390/md11030788
Article

Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 3 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 4 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan 5 Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan 6 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan 7 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 9 January 2013; in revised form: 6 February 2013 / Accepted: 19 February 2013 / Published: 12 March 2013
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Abstract: Five new eunicellin-based diterpenoids, krempfielins E–I (15) and seven known compounds (612) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. Metabolites 5, 6, 10 and 12 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 6 and 10 could potently inhibit the accumulation of the pro-inflammatory iNOS protein, and 6 and 12 could significantly reduce the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
Keywords: eunicellin-based diterpenoids; Cladiella krempfi; cytotoxicity; anti-inflammatory agents

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MDPI and ACS Style

Tai, C.-J.; Su, J.-H.; Huang, C.-Y.; Huang, M.-S.; Wen, Z.-H.; Dai, C.-F.; Sheu, J.-H. Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi. Mar. Drugs 2013, 11, 788-799.

AMA Style

Tai C-J, Su J-H, Huang C-Y, Huang M-S, Wen Z-H, Dai C-F, Sheu J-H. Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi. Marine Drugs. 2013; 11(3):788-799.

Chicago/Turabian Style

Tai, Chi-Jen; Su, Jui-Hsin; Huang, Chiung-Yao; Huang, Ming-Shyan; Wen, Zhi-Hong; Dai, Chang-Feng; Sheu, Jyh-Horng. 2013. "Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi." Mar. Drugs 11, no. 3: 788-799.

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