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Mar. Drugs 2013, 11(3), 817-829; doi:10.3390/md11030817
Article

New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells

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Received: 7 November 2012; in revised form: 30 January 2013 / Accepted: 26 February 2013 / Published: 12 March 2013
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Abstract: Seven new azalomycin F analogs (17) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F5a monoester (1), 23-valine demalonylazalomycin F5a ester (2), 23-(6-methyl)heptanoic acid demalonylazalomycins F3a ester (3), F4a ester (4) and F5a ester (5), 23-(9-methyl)decanoic acid demalonylazalomycin F4a ester (6) and 23-(10-methyl)undecanoic acid demalony lazalomycin F4a ester (7). Their structures were established by their spectroscopic data and by comparing with those of azalomycins F3a, F4a and F5a. Biological assays exhibited that 17 showed broad-spectrum antimicrobial and anti HCT-116 activities.
Keywords: azalomycin F; Streptomyces sp. 211726; cytotoxicity; antimicrobial activity azalomycin F; Streptomyces sp. 211726; cytotoxicity; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yuan, G.; Hong, K.; Lin, H.; She, Z.; Li, J. New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells. Mar. Drugs 2013, 11, 817-829.

AMA Style

Yuan G, Hong K, Lin H, She Z, Li J. New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells. Marine Drugs. 2013; 11(3):817-829.

Chicago/Turabian Style

Yuan, Ganjun; Hong, Kui; Lin, Haipeng; She, Zhigang; Li, Jia. 2013. "New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells." Mar. Drugs 11, no. 3: 817-829.



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