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New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells
College of Bioscience and Engineering, Jiangxi Agricultural University, 1101 Zhimin Road, Nanchang 330045, China
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, China
School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China
National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai 201203, China
* Author to whom correspondence should be addressed.
Received: 7 November 2012; in revised form: 30 January 2013 / Accepted: 26 February 2013 / Published: 12 March 2013
Abstract: Seven new azalomycin F analogs (1–7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F5a monoester (1), 23-valine demalonylazalomycin F5a ester (2), 23-(6-methyl)heptanoic acid demalonylazalomycins F3a ester (3), F4a ester (4) and F5a ester (5), 23-(9-methyl)decanoic acid demalonylazalomycin F4a ester (6) and 23-(10-methyl)undecanoic acid demalony lazalomycin F4a ester (7). Their structures were established by their spectroscopic data and by comparing with those of azalomycins F3a, F4a and F5a. Biological assays exhibited that 1–7 showed broad-spectrum antimicrobial and anti HCT-116 activities.
Keywords: azalomycin F; Streptomyces sp. 211726; cytotoxicity; antimicrobial activity
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Yuan, G.; Hong, K.; Lin, H.; She, Z.; Li, J. New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells. Mar. Drugs 2013, 11, 817-829.
Yuan G, Hong K, Lin H, She Z, Li J. New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells. Marine Drugs. 2013; 11(3):817-829.
Yuan, Ganjun; Hong, Kui; Lin, Haipeng; She, Zhigang; Li, Jia. 2013. "New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells." Mar. Drugs 11, no. 3: 817-829.