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Mar. Drugs 2013, 11(12), 4993-5007; doi:10.3390/md11124993
Article

The Effect of Eating Sea Cucumber Jelly on Candida Load in the Oral Cavity of Elderly Individuals in a Nursing Home

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Received: 9 October 2013; in revised form: 15 November 2013 / Accepted: 26 November 2013 / Published: 11 December 2013
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Abstract: We conducted a double-blind randomized controlled study of elderly individuals in a nursing home to investigate the effect of the consumption of jelly containing sea cucumber on their oral Candida load. The jelly contained a hydrolysate of the sea cucumber Stichopus japonicus, which contained triterpene glycosides called holotoxins. The holotoxins worked as a fungicide, and their minimum inhibitory concentrations for Candida albicans were 7 µg/mL. Eight individuals in the nursing home took the sea cucumber jelly for a week and their oral Candida were counted before and after the intervention. Nine individuals took a control jelly without S. japonicus. The sea cucumber jelly showed inhibitory effects on the oral Candida. Thus, daily consumption of the S. japonicus jelly has the potential to reduce the oral Candida load in the elderly in nursing homes.
Keywords: Stichopus japonicus; holotoxin; Candida; oral care; elderly in nursing home Stichopus japonicus; holotoxin; Candida; oral care; elderly in nursing home
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yano, A.; Abe, A.; Aizawa, F.; Yamada, H.; Minami, K.; Matsui, M.; Kishi, M. The Effect of Eating Sea Cucumber Jelly on Candida Load in the Oral Cavity of Elderly Individuals in a Nursing Home. Mar. Drugs 2013, 11, 4993-5007.

AMA Style

Yano A, Abe A, Aizawa F, Yamada H, Minami K, Matsui M, Kishi M. The Effect of Eating Sea Cucumber Jelly on Candida Load in the Oral Cavity of Elderly Individuals in a Nursing Home. Marine Drugs. 2013; 11(12):4993-5007.

Chicago/Turabian Style

Yano, Akira; Abe, Akiko; Aizawa, Fumie; Yamada, Hidetoshi; Minami, Kentaro; Matsui, Miki; Kishi, Mitsuo. 2013. "The Effect of Eating Sea Cucumber Jelly on Candida Load in the Oral Cavity of Elderly Individuals in a Nursing Home." Mar. Drugs 11, no. 12: 4993-5007.


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