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Mar. Drugs 2013, 11(12), 4973-4992; doi:10.3390/md11124973
Article

The Effect of 17α-Ethynylestradiol on Steroidogenesis and Gonadal Cytokine Gene Expression Is Related to the Reproductive Stage in Marine Hermaphrodite Fish

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Received: 17 October 2013; in revised form: 21 November 2013 / Accepted: 22 November 2013 / Published: 11 December 2013
(This article belongs to the Special Issue Marine Fish Endocrine Disruption)
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Abstract: Pollutants have been reported to disrupt the endocrine system of marine animals, which may be exposed through contaminated seawater or through the food chain. Although 17α-ethynylestradiol (EE2), a drug used in hormone therapies, is widely present in the aquatic environment, current knowledge on the sensitivity of marine fish to estrogenic pollutants is limited. We report the effect of the dietary intake of 5 µg EE2/g food on different processes of testicular physiology, ranging from steroidogenesis to pathogen recognition, at both pre-spermatogenesis (pre-SG) and spermatogenesis (SG) reproductive stages, of gilthead seabream (Sparus aurata L.), a marine hermaphrodite teleost. A differential effect between pre-SG and SG specimens was detected in the sex steroid serum levels and in the expression profile of some steroidogenic-relevant molecules, vitellogenin, double sex- and mab3-related transcription factor 1 and some hormone receptors. Interestingly, EE2 modified the expression pattern of some immune molecules involved in testicular physiology. These differences probably reflect a developmental adjustment of the sensitivity to EE2 in the gilthead seabream gonad.
Keywords: 17α-ethynylestradiol; steroidogenic enzymes; testis; immune-related molecules; gilthead seabream 17α-ethynylestradiol; steroidogenic enzymes; testis; immune-related molecules; gilthead seabream
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Cabas, I.; Chaves-Pozo, E.; García-Alcázar, A.; Meseguer, J.; Mulero, V.; García-Ayala, A. The Effect of 17α-Ethynylestradiol on Steroidogenesis and Gonadal Cytokine Gene Expression Is Related to the Reproductive Stage in Marine Hermaphrodite Fish. Mar. Drugs 2013, 11, 4973-4992.

AMA Style

Cabas I, Chaves-Pozo E, García-Alcázar A, Meseguer J, Mulero V, García-Ayala A. The Effect of 17α-Ethynylestradiol on Steroidogenesis and Gonadal Cytokine Gene Expression Is Related to the Reproductive Stage in Marine Hermaphrodite Fish. Marine Drugs. 2013; 11(12):4973-4992.

Chicago/Turabian Style

Cabas, Isabel; Chaves-Pozo, Elena; García-Alcázar, Alicia; Meseguer, José; Mulero, Victoriano; García-Ayala, Alfonsa. 2013. "The Effect of 17α-Ethynylestradiol on Steroidogenesis and Gonadal Cytokine Gene Expression Is Related to the Reproductive Stage in Marine Hermaphrodite Fish." Mar. Drugs 11, no. 12: 4973-4992.


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