Mar. Drugs 2013, 11(11), 4487-4509; doi:10.3390/md11114487
Article

Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites

1,†email, 1,†email, 2email, 3email, 3email and 1,* email
Received: 30 August 2013; in revised form: 26 September 2013 / Accepted: 9 October 2013 / Published: 11 November 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.
Keywords: salarins; tulearins; Fascaplysinopsis sp.; sponge; nitrogenous macrolide; leukemia cells
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MDPI and ACS Style

Zur, L.G.; Bishara, A.; Aknin, M.; Neumann, D.; Ben-Califa, N.; Kashman, Y. Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites. Mar. Drugs 2013, 11, 4487-4509.

AMA Style

Zur LG, Bishara A, Aknin M, Neumann D, Ben-Califa N, Kashman Y. Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites. Marine Drugs. 2013; 11(11):4487-4509.

Chicago/Turabian Style

Zur, Lee G.; Bishara, Ashgan; Aknin, Maurice; Neumann, Drorit; Ben-Califa, Nathalie; Kashman, Yoel. 2013. "Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites." Mar. Drugs 11, no. 11: 4487-4509.


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