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Chlorinated Didemnins from the Tunicate Trididemnum solidum
Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA
* Authors to whom correspondence should be addressed.
Received: 23 September 2013; in revised form: 25 October 2013 / Accepted: 29 October 2013 / Published: 11 November 2013
Abstract: Chemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectroscopic analysis. The isolated compounds 1–4 were tested for their anti-inflammatory activity using in vitro assays for inhibition of inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB) activity. The anti-cell proliferative activity of the above compounds was also evaluated against four solid tumor cell lines.
Keywords: chlorinated didemnins; anti-inflammatory activity; Trididemnum solidum
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Ankisetty, S.; Khan, S.I.; Avula, B.; Gochfeld, D.; Khan, I.A.; Slattery, M. Chlorinated Didemnins from the Tunicate Trididemnum solidum. Mar. Drugs 2013, 11, 4478-4486.
Ankisetty S, Khan SI, Avula B, Gochfeld D, Khan IA, Slattery M. Chlorinated Didemnins from the Tunicate Trididemnum solidum. Marine Drugs. 2013; 11(11):4478-4486.
Ankisetty, Sridevi; Khan, Shabana I.; Avula, Bharathi; Gochfeld, Deborah; Khan, Ikhlas A.; Slattery, Marc. 2013. "Chlorinated Didemnins from the Tunicate Trididemnum solidum." Mar. Drugs 11, no. 11: 4478-4486.