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Mar. Drugs 2013, 11(11), 4478-4486; doi:10.3390/md11114478

Chlorinated Didemnins from the Tunicate Trididemnum solidum

1,* , 1,2
Received: 23 September 2013 / Revised: 25 October 2013 / Accepted: 29 October 2013 / Published: 11 November 2013
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Chemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectroscopic analysis. The isolated compounds 14 were tested for their anti-inflammatory activity using in vitro assays for inhibition of inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB) activity. The anti-cell proliferative activity of the above compounds was also evaluated against four solid tumor cell lines.
Keywords: chlorinated didemnins; anti-inflammatory activity; Trididemnum solidum chlorinated didemnins; anti-inflammatory activity; Trididemnum solidum
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Ankisetty, S.; Khan, S.I.; Avula, B.; Gochfeld, D.; Khan, I.A.; Slattery, M. Chlorinated Didemnins from the Tunicate Trididemnum solidum. Mar. Drugs 2013, 11, 4478-4486.

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