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Mar. Drugs 2013, 11(11), 4478-4486; doi:10.3390/md11114478
Article

Chlorinated Didemnins from the Tunicate Trididemnum solidum

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Received: 23 September 2013 / Revised: 25 October 2013 / Accepted: 29 October 2013 / Published: 11 November 2013
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Abstract

Chemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectroscopic analysis. The isolated compounds 14 were tested for their anti-inflammatory activity using in vitro assays for inhibition of inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB) activity. The anti-cell proliferative activity of the above compounds was also evaluated against four solid tumor cell lines.
Keywords: chlorinated didemnins; anti-inflammatory activity; Trididemnum solidum chlorinated didemnins; anti-inflammatory activity; Trididemnum solidum
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ankisetty, S.; Khan, S.I.; Avula, B.; Gochfeld, D.; Khan, I.A.; Slattery, M. Chlorinated Didemnins from the Tunicate Trididemnum solidum. Mar. Drugs 2013, 11, 4478-4486.

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