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Chlorinated Didemnins from the Tunicate Trididemnum solidum
AbstractChemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectroscopic analysis. The isolated compounds 1–4 were tested for their anti-inflammatory activity using in vitro assays for inhibition of inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB) activity. The anti-cell proliferative activity of the above compounds was also evaluated against four solid tumor cell lines.
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Ankisetty, S.; Khan, S.I.; Avula, B.; Gochfeld, D.; Khan, I.A.; Slattery, M. Chlorinated Didemnins from the Tunicate Trididemnum solidum. Mar. Drugs 2013, 11, 4478-4486.View more citation formats
Ankisetty S, Khan SI, Avula B, Gochfeld D, Khan IA, Slattery M. Chlorinated Didemnins from the Tunicate Trididemnum solidum. Marine Drugs. 2013; 11(11):4478-4486.Chicago/Turabian Style
Ankisetty, Sridevi; Khan, Shabana I.; Avula, Bharathi; Gochfeld, Deborah; Khan, Ikhlas A.; Slattery, Marc. 2013. "Chlorinated Didemnins from the Tunicate Trididemnum solidum." Mar. Drugs 11, no. 11: 4478-4486.