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Mar. Drugs 2013, 11(11), 4478-4486; doi:10.3390/md11114478
Article

Chlorinated Didemnins from the Tunicate Trididemnum solidum

1,* , 1,2
,
2
,
2
,
1,2
 and
1,2,*
1 Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA 2 National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA
* Authors to whom correspondence should be addressed.
Received: 23 September 2013 / Revised: 25 October 2013 / Accepted: 29 October 2013 / Published: 11 November 2013
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Abstract

Chemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectroscopic analysis. The isolated compounds 14 were tested for their anti-inflammatory activity using in vitro assays for inhibition of inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB) activity. The anti-cell proliferative activity of the above compounds was also evaluated against four solid tumor cell lines.
Keywords: chlorinated didemnins; anti-inflammatory activity; Trididemnum solidum chlorinated didemnins; anti-inflammatory activity; Trididemnum solidum
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ankisetty, S.; Khan, S.I.; Avula, B.; Gochfeld, D.; Khan, I.A.; Slattery, M. Chlorinated Didemnins from the Tunicate Trididemnum solidum. Mar. Drugs 2013, 11, 4478-4486.

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