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Mar. Drugs 2013, 11(11), 4464-4477; doi:10.3390/md11114464

Isolation and Structural Characterization of a Novel Antioxidant Mannoglucan from a Marine Bubble Snail, Bullacta exarata (Philippi)

1,2,* , 1
1 College of Biosystem Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Xihu District, Hangzhou 310058, China 2 Fuli Institute of Food Science, Zhejiang University, Hangzhou 310058, China 3 Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hung Hom 990077, Kowloon, Hong Kong These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 11 September 2013 / Revised: 12 October 2013 / Accepted: 12 October 2013 / Published: 11 November 2013
(This article belongs to the collection Marine Polysaccharides)
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Bullacta exarata is one of the most economically important aquatic species in China, noted for not only its delicious taste and nutritional value, but also for its pharmacological activities. In order to explore its potential in medical applications, a mannoglucan designated as BEPS-IB was isolated and purified from the foot muscle of B. exarata after papain digestion. Chemical composition analysis indicated BEPS-IB contained mainly d-glucose and d-mannose in a molar ratio of 1:0.52, with an average molecular weight of about 94 kDa. The linkage information was determined by methylation analysis, and the anomeric configuration and chain linkage were confirmed by IR and 2D NMR. The results indicated BEPS-IB was composed of Glcp6Manp heptasaccharide repeating unit in the backbone, with occasional branch chains of mannose residues (14%) occurring in the backbone mannose. Further antioxidant assay indicated BEPS-IB exhibited positive antioxidant activity in scavenging superoxide radicals and reducing power. This is the first report on the structure and bioactivity of the mannoglucan from the B. exarata.
Keywords: Bullacta exarata; structure; polysaccharide; mannoglucan Bullacta exarata; structure; polysaccharide; mannoglucan
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Liu, D.; Liao, N.; Ye, X.; Hu, Y.; Wu, D.; Guo, X.; Zhong, J.; Wu, J.; Chen, S. Isolation and Structural Characterization of a Novel Antioxidant Mannoglucan from a Marine Bubble Snail, Bullacta exarata (Philippi). Mar. Drugs 2013, 11, 4464-4477.

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