Abstract: Deep ocean water (DOW) has, in previous studies, been found to be a novel anti-obesity drink and useful in raising Monascus-produced monascin and ankaflavin levels. This may resolve the limited anti-obesity ability of red mold dioscorea (RMD) known as the Monascus purpureus-fermented Disocorea batatas. This study aims to compare the anti-obesity effect of DOW-cultured RMD (DOW-RMD) and ultra-pure water-cultured RMD (UPW-RMD) in rats fed on a high fat diet. Moreover, the effect of ions composition of DOW and DOW-influenced functional metabolites change of RMD on the differentiation and lipogenesis regulation were investigated using 3T3-L1 pre-adipocytes. In the animal test, compared to UPW-RMD, DOW-RMD possessed better ability to inhibit increases in weight gain, and better feed efficiency, body-fat pad and cross-sectional area of adipocytes. In the cell test, the anti-obesity abilities of DOW-RMD in inhibiting PPARγ and C/EBPα expression in differentiation and lipoprotein lipase activity in lipogenesis were contributed to by the DOW-increased monascin and ankaflavin levels and the ions of DOW, respectively.
Keywords: deep ocean water; obesity; Monascus; monascin; ankaflavin
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Wang, L.-C.; Lung, T.-Y.; Kung, Y.-H.; Wang, J.-J.; Tsai, T.-Y.; Wei, B.-L.; Pan, T.-M.; Lee, C.-L. Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture Water. Mar. Drugs 2013, 11, 3902-3925.
Wang L-C, Lung T-Y, Kung Y-H, Wang J-J, Tsai T-Y, Wei B-L, Pan T-M, Lee C-L. Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture Water. Marine Drugs. 2013; 11(10):3902-3925.
Wang, Li-Chun; Lung, Tzu-Ying; Kung, Yi-Hsin; Wang, Jyh-Jye; Tsai, Tsung-Yu; Wei, Bai-Luh; Pan, Tzu-Ming; Lee, Chun-Lin. 2013. "Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture Water." Mar. Drugs 11, no. 10: 3902-3925.