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Mar. Drugs 2013, 11(10), 3891-3901; doi:10.3390/md11103891
Article

New Spirotetronate Antibiotics, Lobophorins H and I, from a South China Sea-Derived Streptomyces sp. 12A35

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Received: 4 July 2013; in revised form: 12 August 2013 / Accepted: 22 August 2013 / Published: 15 October 2013
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Abstract: Strain 12A35 was isolated from a deep-sea sediment collected from the South China Sea and showed promising antibacterial activities. It was identified as Streptomyces sp. by the 16S rDNA sequence analysis. Bioassay-guided fractionation using HP20 adsorption, flash chromatography over silica gel and octadecylsilyl (ODS) and semi-preparative HPLC, led to the isolation and purification of five metabolites from the fermentation culture of 12A35. Two new spirotetronate antibiotics, lobophorins H (1) and I (2), along with three known analogues, O-β-kijanosyl-(1→17)-kijanolide (3), lobophorins B (4) and F (5) were characterized by 1D, 2D-NMR and MS data. These compounds exhibited significant inhibitory activities against Bacillus subtilis. Compounds 1 and 5 exhibited moderate activities against Staphylococcus aureus. In particular, the new compound lobophorin H (1) showed similar antibacterial activities against B. subtilis CMCC63501 to ampicillin.
Keywords: lobophorins; spirotetronate antibiotics; antimicrobial; Streptomyces; South China Sea-derived actinomycete lobophorins; spirotetronate antibiotics; antimicrobial; Streptomyces; South China Sea-derived actinomycete
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pan, H.-Q.; Zhang, S.-Y.; Wang, N.; Li, Z.-L.; Hua, H.-M.; Hu, J.-C.; Wang, S.-J. New Spirotetronate Antibiotics, Lobophorins H and I, from a South China Sea-Derived Streptomyces sp. 12A35. Mar. Drugs 2013, 11, 3891-3901.

AMA Style

Pan H-Q, Zhang S-Y, Wang N, Li Z-L, Hua H-M, Hu J-C, Wang S-J. New Spirotetronate Antibiotics, Lobophorins H and I, from a South China Sea-Derived Streptomyces sp. 12A35. Marine Drugs. 2013; 11(10):3891-3901.

Chicago/Turabian Style

Pan, Hua-Qi; Zhang, Song-Ya; Wang, Nan; Li, Zhan-Lin; Hua, Hui-Ming; Hu, Jiang-Chun; Wang, Shu-Jin. 2013. "New Spirotetronate Antibiotics, Lobophorins H and I, from a South China Sea-Derived Streptomyces sp. 12A35." Mar. Drugs 11, no. 10: 3891-3901.



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