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Mar. Drugs 2013, 11(10), 3891-3901; doi:10.3390/md11103891
Article

New Spirotetronate Antibiotics, Lobophorins H and I, from a South China Sea-Derived Streptomyces sp. 12A35

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1,* , 2,*  and 2
1 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China 2 Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
* Authors to whom correspondence should be addressed.
Received: 4 July 2013 / Revised: 12 August 2013 / Accepted: 22 August 2013 / Published: 15 October 2013
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Abstract

Strain 12A35 was isolated from a deep-sea sediment collected from the South China Sea and showed promising antibacterial activities. It was identified as Streptomyces sp. by the 16S rDNA sequence analysis. Bioassay-guided fractionation using HP20 adsorption, flash chromatography over silica gel and octadecylsilyl (ODS) and semi-preparative HPLC, led to the isolation and purification of five metabolites from the fermentation culture of 12A35. Two new spirotetronate antibiotics, lobophorins H (1) and I (2), along with three known analogues, O-β-kijanosyl-(1→17)-kijanolide (3), lobophorins B (4) and F (5) were characterized by 1D, 2D-NMR and MS data. These compounds exhibited significant inhibitory activities against Bacillus subtilis. Compounds 1 and 5 exhibited moderate activities against Staphylococcus aureus. In particular, the new compound lobophorin H (1) showed similar antibacterial activities against B. subtilis CMCC63501 to ampicillin.
Keywords: lobophorins; spirotetronate antibiotics; antimicrobial; Streptomyces; South China Sea-derived actinomycete lobophorins; spirotetronate antibiotics; antimicrobial; Streptomyces; South China Sea-derived actinomycete
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pan, H.-Q.; Zhang, S.-Y.; Wang, N.; Li, Z.-L.; Hua, H.-M.; Hu, J.-C.; Wang, S.-J. New Spirotetronate Antibiotics, Lobophorins H and I, from a South China Sea-Derived Streptomyces sp. 12A35. Mar. Drugs 2013, 11, 3891-3901.

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