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Mar. Drugs 2012, 10(8), 1647-1661; doi:10.3390/md10081647

Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea Cucumber

1,2,3,†
,
1,†
,
2,3
,
1
,
1
and
1,*
1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
2
School of Pharmaceutical Sciences, Central South University, Changsha 410078, China
3
Xiangya Hospital, Central South University, Changsha 410008, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 21 May 2012 / Revised: 3 July 2012 / Accepted: 24 July 2012 / Published: 10 August 2012
(This article belongs to the Special Issue Marine Glycoconjugates)
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Abstract

Fucosylated chondroitin sulfate (FuCS), a kind of complex glycosaminoglycan from sea cucumber, has potent anticoagulant activity. In order to understand the relationship between structures and activity, the depolymerized FuCS (dFuCS) was chosen to prepare its derivates by selective substitution at OH groups. Its O-acylation was carried out in a homogeneous way using carboxylic acid anhydrides. The structures of O-acylated derivatives were characterized by NMR. The results indicated that the 4-O-sulfated fucose residues may be easier to be acylated than the other ones in the sulfated fucose branches. But the O-acylation was always accompanied by the β-elimination, and the degree of elimination was higher as that of acylation was higher. The results of clotting assay indicated that the effect of partial O-acylation of the dFuCS on their anticoagulant potency was not significant and the O-acylation of 2-OH groups of 4-O-sulfated fucose units did not affect the anticoagulant activity. View Full-Text
Keywords: sea cucumber; fucosylated chondroitin sulfate; glycosaminoglycan; acylation; anticoagulant activity sea cucumber; fucosylated chondroitin sulfate; glycosaminoglycan; acylation; anticoagulant activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Gao, N.; Wu, M.; Liu, S.; Lian, W.; Li, Z.; Zhao, J. Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea Cucumber. Mar. Drugs 2012, 10, 1647-1661.

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