Mar. Drugs 2012, 10(4), 793-811; doi:10.3390/md10040793
Review

Fucanomics and Galactanomics: Marine Distribution, Medicinal Impact, Conceptions, and Challenges

Program of Glycobiology, Institute of Medical Biochemistry, and University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21941-590, Brazil
Received: 21 February 2012; in revised form: 21 March 2012 / Accepted: 22 March 2012 / Published: 29 March 2012
(This article belongs to the Special Issue Marine Glycoconjugates)
PDF Full-text Download PDF Full-Text [222 KB, Updated Version, uploaded 24 April 2012 14:01 CEST]
The original version is still available [242 KB, uploaded 29 March 2012 10:09 CEST]
Abstract: Glycomics turned out to be a very extensive project where its subdivision is consequently emerging. This is seen by the growing number of terminologies used to define subprojects concerning particular classes of bioactive carbohydrates. Sulfated fucans (SFs) and sulfated galactans (SGs) are relatively new classes of sulfated polysaccharides (SPs) that occur mostly in marine organisms, and exhibit a broad range of medicinal effects. Their structures are taxonomically dependent, and their therapeutic actions include benefits in inflammation, coagulation, thrombosis, angiogenesis, cancer, oxidation, and infections. Some red algae, marine angiosperm and invertebrates express SPs of unique structures composed of regular repeating oligomeric units of well-defined sulfation patterns. This fine pattern of structural regularity is quite rare among any naturally occurring long SPs, and enables accurate structure-biofunction correlations. Seeing that, fucanomics and galactanomics may comprise distinguished glycomics subprojects. We hereby discuss the relevance that justifies the international recognition of these subprojects in the current glycomics age associated with the beneficial outcomes that these glycans may offer in drug development.
Keywords: fucanome; fucanomics; galactanome; galactanomics; glycome; glycomics; sulfated fucan; sulfated galactan

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Pomin, V.H. Fucanomics and Galactanomics: Marine Distribution, Medicinal Impact, Conceptions, and Challenges. Mar. Drugs 2012, 10, 793-811.

AMA Style

Pomin VH. Fucanomics and Galactanomics: Marine Distribution, Medicinal Impact, Conceptions, and Challenges. Marine Drugs. 2012; 10(4):793-811.

Chicago/Turabian Style

Pomin, Vitor H. 2012. "Fucanomics and Galactanomics: Marine Distribution, Medicinal Impact, Conceptions, and Challenges." Mar. Drugs 10, no. 4: 793-811.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert