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• Meginley, R
• Gupta, P
• Schulz, T
• McLean, A
• Robins, A
• West, L
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• Meginley, R
• Gupta, P
• Schulz, T
• McLean, A
• Robins, A
• West, L
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• Meginley, R
• Gupta, P
• Schulz, T
• McLean, A
• Robins, A
• West, L

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Mar. Drugs 2012, 10(8), 1662-1670; doi:10.3390/md10081662

Article

Briareolate Esters from the Gorgonian Briareum asbestinum

Rian J. Meginley ¹ , Prasoon Gupta ¹ , Thomas C. Schulz ² , Amanda B. McLean ³ , Allan J. Robins ²  and Lyndon M. West ^1,*

¹ Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA ² Viacyte Inc., 111 Riverbend Rd, Athens, GA 30602, USA ³ Department of Biochemistry and Molecular Biology, The University of Georgia, Athens, GA 30602, USA

* Author to whom correspondence should be addressed.

Received: 5 June 2012; in revised form: 25 July 2012 / Accepted: 30 July 2012 / Published: 10 August 2012

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Abstract: Two new briarane diterpenoids briareolate esters J (1) and K (2) were isolated from the methanolic extract of the octocoral Briareum asbestinum collected off the coast of Boca Raton, Florida. The structures of briaranes 1 and 2 were elucidated by interpretation of spectroscopic data. Briareolate ester K (2) showed weak growth inhibition activity against human embryonic stem cells (BG02).

Keywords: Briareum asbestinum; octocoral; briarane; briareolate ester; human embryonic stem cell

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