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Mar. Drugs 2012, 10(7), 1433-1444; doi:10.3390/md10071433
Article

Three New Cembranoids from the Taiwanese Soft Coral Sarcophyton ehrenbergi

1,2
, 3
 and 1,3,*
1 Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan 2 Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan 3 Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 20 May 2012 / Revised: 10 June 2012 / Accepted: 16 June 2012 / Published: 27 June 2012
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Abstract

In order to search for new bioactive substances from marine organisms, we have investigated the acetone extracts of the soft coral Sarcophyton ehrenbergi collected at San-Hsian-Tai, Taitong County, Taiwan. Chromatographic fractionation of the extracts of the octocoral S. ehrenbergi led to the isolation of three new cembranoids, (+)-12-ethoxycarbonyl-11Z-sarcophine (1), ehrenbergol A and B (2 and 3). The structures of these isolated metabolites were elucidated through extensive spectroscopic analyses. Moreover, metabolites 13 were evaluated in vitro for their cytotoxicity towards selected cancer cell lines and antiviral activity against human cytomegalovirus (HCMV).
Keywords: Sarcophyton ehrenbergi; cembranoids; cytotoxicity; anti-HCMV Sarcophyton ehrenbergi; cembranoids; cytotoxicity; anti-HCMV
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, S.-K.; Hsieh, M.-K.; Duh, C.-Y. Three New Cembranoids from the Taiwanese Soft Coral Sarcophyton ehrenbergi. Mar. Drugs 2012, 10, 1433-1444.

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