Three New Cembranoids from the Taiwanese Soft Coral Sarcophyton ehrenbergi

doi:10.3390/md10071433

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Mar. Drugs 2012, 10(7), 1433-1444; doi:10.3390/md10071433

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Three New Cembranoids from the Taiwanese Soft Coral Sarcophyton ehrenbergi

Shang-Kwei Wang^1,2, Mu-Keng Hsieh³ and Chang-Yih Duh^1,3,*

¹ Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan ² Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan ³ Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan

* Author to whom correspondence should be addressed.

Received: 20 May 2012; in revised form: 10 June 2012 / Accepted: 16 June 2012 / Published: 27 June 2012

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Abstract: In order to search for new bioactive substances from marine organisms, we have investigated the acetone extracts of the soft coral Sarcophyton ehrenbergi collected at San-Hsian-Tai, Taitong County, Taiwan. Chromatographic fractionation of the extracts of the octocoral S. ehrenbergi led to the isolation of three new cembranoids, (+)-12-ethoxycarbonyl-11Z-sarcophine (1), ehrenbergol A and B (2 and 3). The structures of these isolated metabolites were elucidated through extensive spectroscopic analyses. Moreover, metabolites 1–3 were evaluated in vitro for their cytotoxicity towards selected cancer cell lines and antiviral activity against human cytomegalovirus (HCMV).

Keywords: Sarcophyton ehrenbergi; cembranoids; cytotoxicity; anti-HCMV

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Cite This Article

MDPI and ACS Style

Wang, S.-K.; Hsieh, M.-K.; Duh, C.-Y. Three New Cembranoids from the Taiwanese Soft Coral Sarcophyton ehrenbergi. Mar. Drugs 2012, 10, 1433-1444.

AMA Style

Wang S-K, Hsieh M-K, Duh C-Y. Three New Cembranoids from the Taiwanese Soft Coral Sarcophyton ehrenbergi. Marine Drugs. 2012; 10(7):1433-1444.

Chicago/Turabian Style

Wang, Shang-Kwei; Hsieh, Mu-Keng; Duh, Chang-Yih. 2012. "Three New Cembranoids from the Taiwanese Soft Coral Sarcophyton ehrenbergi." Mar. Drugs 10, no. 7: 1433-1444.

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