Mar. Drugs 2012, 10(7), 1422-1432; doi:10.3390/md10071422
Article

Polyoxygenated Sterols from the South China Sea Soft Coral Sinularia sp.

Rui Li 1 email, Chang-Lun Shao 1 email, Xin Qi 1 email, Xiu-Bao Li 2 email, Jing Li 1 email, Ling-Ling Sun 1 email and Chang-Yun Wang 1,* email
1 Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China 2 South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510000, China
* Author to whom correspondence should be addressed.
Received: 28 March 2012; in revised form: 29 May 2012 / Accepted: 8 June 2012 / Published: 26 June 2012
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Abstract: Chemical investigation of the ethanol extract of soft coral Sinularia sp. collected from the South China Sea led to the isolation of three new polyoxygenated sterols, (3S,23R,24S)-ergost-5-ene-3β,23α,25-triol (1), (24S)-ergostane-6-acetate-3β,5α,6β,25-tetraol (2), (24S)-ergostane-6-acetate-3β,6β,12β,25-tetraol (3) together with three known ones (4–6). The structures, including relative configurations of the new compounds (1–3), were elucidated by detailed analysis of spectroscopic data (IR, UV, NMR, MS) and by comparison with related reported compounds. The absolute configuration of 1 was further determined by modified Mosher’s method. Compound 5 exhibited moderate cytotoxicity against K562 cell line with an IC50 value of 3.18 μM, but also displayed strong lethality toward the brine shrimp Artemia salina with a LC50 value of 0.96 μM.
Keywords: soft coral; Sinularia sp.; polyoxygenated sterols; cytotoxicity

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MDPI and ACS Style

Li, R.; Shao, C.-L.; Qi, X.; Li, X.-B.; Li, J.; Sun, L.-L.; Wang, C.-Y. Polyoxygenated Sterols from the South China Sea Soft Coral Sinularia sp.. Mar. Drugs 2012, 10, 1422-1432.

AMA Style

Li R, Shao C-L, Qi X, Li X-B, Li J, Sun L-L, Wang C-Y. Polyoxygenated Sterols from the South China Sea Soft Coral Sinularia sp.. Marine Drugs. 2012; 10(7):1422-1432.

Chicago/Turabian Style

Li, Rui; Shao, Chang-Lun; Qi, Xin; Li, Xiu-Bao; Li, Jing; Sun, Ling-Ling; Wang, Chang-Yun. 2012. "Polyoxygenated Sterols from the South China Sea Soft Coral Sinularia sp.." Mar. Drugs 10, no. 7: 1422-1432.

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