Polyoxygenated Sterols from the South China Sea Soft Coral Sinularia sp.
AbstractChemical investigation of the ethanol extract of soft coral Sinularia sp. collected from the South China Sea led to the isolation of three new polyoxygenated sterols, (3S,23R,24S)-ergost-5-ene-3β,23α,25-triol (1), (24S)-ergostane-6-acetate-3β,5α,6β,25-tetraol (2), (24S)-ergostane-6-acetate-3β,6β,12β,25-tetraol (3) together with three known ones (4–6). The structures, including relative configurations of the new compounds (1–3), were elucidated by detailed analysis of spectroscopic data (IR, UV, NMR, MS) and by comparison with related reported compounds. The absolute configuration of 1 was further determined by modified Mosher’s method. Compound 5 exhibited moderate cytotoxicity against K562 cell line with an IC50 value of 3.18 μM, but also displayed strong lethality toward the brine shrimp Artemia salina with a LC50 value of 0.96 μM. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 510 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Li, R.; Shao, C.-L.; Qi, X.; Li, X.-B.; Li, J.; Sun, L.-L.; Wang, C.-Y. Polyoxygenated Sterols from the South China Sea Soft Coral Sinularia sp.. Mar. Drugs 2012, 10, 1422-1432.
Li R, Shao C-L, Qi X, Li X-B, Li J, Sun L-L, Wang C-Y. Polyoxygenated Sterols from the South China Sea Soft Coral Sinularia sp.. Marine Drugs. 2012; 10(7):1422-1432.Chicago/Turabian Style
Li, Rui; Shao, Chang-Lun; Qi, Xin; Li, Xiu-Bao; Li, Jing; Sun, Ling-Ling; Wang, Chang-Yun. 2012. "Polyoxygenated Sterols from the South China Sea Soft Coral Sinularia sp.." Mar. Drugs 10, no. 7: 1422-1432.