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Mar. Drugs 2012, 10(7), 1422-1432; doi:10.3390/md10071422
Article

Polyoxygenated Sterols from the South China Sea Soft Coral Sinularia sp.

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Received: 28 March 2012 / Revised: 29 May 2012 / Accepted: 8 June 2012 / Published: 26 June 2012
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Abstract

Chemical investigation of the ethanol extract of soft coral Sinularia sp. collected from the South China Sea led to the isolation of three new polyoxygenated sterols, (3S,23R,24S)-ergost-5-ene-3β,23α,25-triol (1), (24S)-ergostane-6-acetate-3β,5α,6β,25-tetraol (2), (24S)-ergostane-6-acetate-3β,6β,12β,25-tetraol (3) together with three known ones (46). The structures, including relative configurations of the new compounds (13), were elucidated by detailed analysis of spectroscopic data (IR, UV, NMR, MS) and by comparison with related reported compounds. The absolute configuration of 1 was further determined by modified Mosher’s method. Compound 5 exhibited moderate cytotoxicity against K562 cell line with an IC50 value of 3.18 μM, but also displayed strong lethality toward the brine shrimp Artemia salina with a LC50 value of 0.96 μM.
Keywords: soft coral; Sinularia sp.; polyoxygenated sterols; cytotoxicity soft coral; Sinularia sp.; polyoxygenated sterols; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, R.; Shao, C.-L.; Qi, X.; Li, X.-B.; Li, J.; Sun, L.-L.; Wang, C.-Y. Polyoxygenated Sterols from the South China Sea Soft Coral Sinularia sp.. Mar. Drugs 2012, 10, 1422-1432.

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