Abstract: Seven new formamido-diterpenes, cavernenes A–D (1–4), kalihinenes E and F (5–6), and kalihipyran C (7), together with five known compounds (8–12), were isolated from the South China Sea sponge Acanthella cavernosa. Structures were established using IR, HRESIMS, 1D and 2D NMR, and single X-ray diffraction techniques. The isolated compounds were assessed for their cytotoxicity against a small panel of human cancer cell lines (HCT-116, A549, HeLa, QGY-7701, and MDA-MB-231) with IC50 values in the range of 6–18 μM. In addition, compound 9 showed weak antifungal activity against Trichophyton rubrum and Microsporum gypseum with MIC values of 8 and 32 μg/mL, respectively, compound 10 displayed weak antifungal activity against fungi Candida albicans, Cryptococcus neoformans, T. rubrum, and M. gypseum with MIC values of 8, 8, 4, and 8 μg/mL, respectively.
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Xu, Y.; Lang, J.-H.; Jiao, W.-H.; Wang, R.-P.; Peng, Y.; Song, S.-J.; Zhang, B.-H.; Lin, H.-W. Formamido-Diterpenes from the South China Sea Sponge Acanthella cavernosa. Mar. Drugs 2012, 10, 1445-1458.
Xu Y, Lang J-H, Jiao W-H, Wang R-P, Peng Y, Song S-J, Zhang B-H, Lin H-W. Formamido-Diterpenes from the South China Sea Sponge Acanthella cavernosa. Marine Drugs. 2012; 10(7):1445-1458.
Xu, Ying; Lang, Jun-Hui; Jiao, Wei-Hua; Wang, Ru-Ping; Peng, Ying; Song, Shao-Jiang; Zhang, Bao-Hua; Lin, Hou-Wen. 2012. "Formamido-Diterpenes from the South China Sea Sponge Acanthella cavernosa." Mar. Drugs 10, no. 7: 1445-1458.