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Formamido-Diterpenes from the South China Sea Sponge Acanthella cavernosa
Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai 200438, China
* Authors to whom correspondence should be addressed.
Received: 15 May 2012; in revised form: 1 June 2012 / Accepted: 16 June 2012 / Published: 2 July 2012
Abstract: Seven new formamido-diterpenes, cavernenes A–D (1–4), kalihinenes E and F (5–6), and kalihipyran C (7), together with five known compounds (8–12), were isolated from the South China Sea sponge Acanthella cavernosa. Structures were established using IR, HRESIMS, 1D and 2D NMR, and single X-ray diffraction techniques. The isolated compounds were assessed for their cytotoxicity against a small panel of human cancer cell lines (HCT-116, A549, HeLa, QGY-7701, and MDA-MB-231) with IC50 values in the range of 6–18 μM. In addition, compound 9 showed weak antifungal activity against Trichophyton rubrum and Microsporum gypseum with MIC values of 8 and 32 μg/mL, respectively, compound 10 displayed weak antifungal activity against fungi Candida albicans, Cryptococcus neoformans, T. rubrum, and M. gypseum with MIC values of 8, 8, 4, and 8 μg/mL, respectively.
Keywords: Acanthella cavernosa; formamido-diterpenes; cytotoxicity; antifungal activity
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MDPI and ACS Style
Xu, Y.; Lang, J.-H.; Jiao, W.-H.; Wang, R.-P.; Peng, Y.; Song, S.-J.; Zhang, B.-H.; Lin, H.-W. Formamido-Diterpenes from the South China Sea Sponge Acanthella cavernosa. Mar. Drugs 2012, 10, 1445-1458.
Xu Y, Lang J-H, Jiao W-H, Wang R-P, Peng Y, Song S-J, Zhang B-H, Lin H-W. Formamido-Diterpenes from the South China Sea Sponge Acanthella cavernosa. Marine Drugs. 2012; 10(7):1445-1458.
Xu, Ying; Lang, Jun-Hui; Jiao, Wei-Hua; Wang, Ru-Ping; Peng, Ying; Song, Shao-Jiang; Zhang, Bao-Hua; Lin, Hou-Wen. 2012. "Formamido-Diterpenes from the South China Sea Sponge Acanthella cavernosa." Mar. Drugs 10, no. 7: 1445-1458.