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Mar. Drugs 2012, 10(7), 1445-1458; doi:10.3390/md10071445
Article

Formamido-Diterpenes from the South China Sea Sponge Acanthella cavernosa

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1 Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China 2 College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China 3 Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai 200438, China
* Authors to whom correspondence should be addressed.
Received: 15 May 2012 / Revised: 1 June 2012 / Accepted: 16 June 2012 / Published: 2 July 2012
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Abstract

Seven new formamido-diterpenes, cavernenes A–D (14), kalihinenes E and F (56), and kalihipyran C (7), together with five known compounds (812), were isolated from the South China Sea sponge Acanthella cavernosa. Structures were established using IR, HRESIMS, 1D and 2D NMR, and single X-ray diffraction techniques. The isolated compounds were assessed for their cytotoxicity against a small panel of human cancer cell lines (HCT-116, A549, HeLa, QGY-7701, and MDA-MB-231) with IC50 values in the range of 6–18 μM. In addition, compound 9 showed weak antifungal activity against Trichophyton rubrum and Microsporum gypseum with MIC values of 8 and 32 μg/mL, respectively, compound 10 displayed weak antifungal activity against fungi Candida albicans, Cryptococcus neoformans, T. rubrum, and M. gypseum with MIC values of 8, 8, 4, and 8 μg/mL, respectively.
Keywords: Acanthella cavernosa; formamido-diterpenes; cytotoxicity; antifungal activity Acanthella cavernosa; formamido-diterpenes; cytotoxicity; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Xu, Y.; Lang, J.-H.; Jiao, W.-H.; Wang, R.-P.; Peng, Y.; Song, S.-J.; Zhang, B.-H.; Lin, H.-W. Formamido-Diterpenes from the South China Sea Sponge Acanthella cavernosa. Mar. Drugs 2012, 10, 1445-1458.

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