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Mar. Drugs 2012, 10(3), 539-550; doi:10.3390/md10030539

Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26

1
Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Provincial Open Laboratory of Applied Microbiology, State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base), South China, Guangdong Institute of Microbiology, Guangzhou 510070, China
2
College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China
*
Author to whom correspondence should be addressed.
Received: 29 November 2011 / Revised: 16 February 2012 / Accepted: 20 February 2012 / Published: 27 February 2012
(This article belongs to the Special Issue Terpenoids of Marine Origin)
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Abstract

Five new oxygenated pimarane diterpenes, named scopararanes C–G (15) were isolated from the culture of a marine sediment-derived fungus Eutypella scoparia FS26 obtained from the South China Sea. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configurations of compounds 15, were determined by CD spectroscopic analysis and comparison with literature data. All isolated compounds (15) were evaluated for their cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) method.
Keywords: pimarane diterpenes; marine sediment-derived fungus; Eutypella scoparia; South China Sea; cytotoxic activity pimarane diterpenes; marine sediment-derived fungus; Eutypella scoparia; South China Sea; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Sun, L.; Li, D.; Tao, M.; Chen, Y.; Dan, F.; Zhang, W. Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26. Mar. Drugs 2012, 10, 539-550.

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