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Terpenes from Marine-Derived Fungi
Mar. Drugs 2012, 10(3), 539-550; doi:10.3390/md10030539
Article

Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26

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Received: 29 November 2011; in revised form: 16 February 2012 / Accepted: 20 February 2012 / Published: 27 February 2012
(This article belongs to the Special Issue Terpenoids of Marine Origin)
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Abstract: Five new oxygenated pimarane diterpenes, named scopararanes C–G (15) were isolated from the culture of a marine sediment-derived fungus Eutypella scoparia FS26 obtained from the South China Sea. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configurations of compounds 15, were determined by CD spectroscopic analysis and comparison with literature data. All isolated compounds (15) were evaluated for their cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) method.
Keywords: pimarane diterpenes; marine sediment-derived fungus; Eutypella scoparia; South China Sea; cytotoxic activity pimarane diterpenes; marine sediment-derived fungus; Eutypella scoparia; South China Sea; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sun, L.; Li, D.; Tao, M.; Chen, Y.; Dan, F.; Zhang, W. Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26. Mar. Drugs 2012, 10, 539-550.

AMA Style

Sun L, Li D, Tao M, Chen Y, Dan F, Zhang W. Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26. Marine Drugs. 2012; 10(3):539-550.

Chicago/Turabian Style

Sun, Li; Li, Dongli; Tao, Meihua; Chen, Yuchan; Dan, Feijun; Zhang, Weimin. 2012. "Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26." Mar. Drugs 10, no. 3: 539-550.


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