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Mar. Drugs 2012, 10(3), 551-558;

Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.

Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
Graduate University of Chinese Academy of Sciences, Beijing 100049, China
Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen D-37077, Germany
Chemical Biological Research Institute, College of Science, Northwest A & F University, Yangling 712100, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 9 January 2012 / Revised: 17 February 2012 / Accepted: 20 February 2012 / Published: 27 February 2012
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Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data. The new angucyclinone derivative showed inhibitory activities against the human cell lines HL-60 (leukemia), A549 (lung adenocarcinoma), and BEL-7402 (hepatoma) with inhibition rates of 68.2%, 55.9%, and 31.7%, respectively, at 100 µM. It appears to have potential as an anticancer agent with selective activity. View Full-Text
Keywords: angucyclinone; epoxybenz[a]anthracene; marine Streptomyces; cytotoxicity angucyclinone; epoxybenz[a]anthracene; marine Streptomyces; cytotoxicity

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Xie, Z.; Liu, B.; Wang, H.; Yang, S.; Zhang, H.; Wang, Y.; Ji, N.; Qin, S.; Laatsch, H. Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.. Mar. Drugs 2012, 10, 551-558.

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