Mar. Drugs 2012, 10(3), 551-558; doi:10.3390/md10030551
Article

Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.

Zeping Xie 1,2,† email, Bing Liu 1,† email, Hongpeng Wang 3 email, Shengxiang Yang 4 email, Hongyu Zhang 1,2 email, Yipeng Wang 1 email, Naiyun Ji 1 email, Song Qin 1,* email and Hartmut Laatsch 3,* email
1 Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China 2 Graduate University of Chinese Academy of Sciences, Beijing 100049, China 3 Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen D-37077, Germany 4 Chemical Biological Research Institute, College of Science, Northwest A & F University, Yangling 712100, China † These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 9 January 2012; in revised form: 17 February 2012 / Accepted: 20 February 2012 / Published: 27 February 2012
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Abstract: Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data. The new angucyclinone derivative showed inhibitory activities against the human cell lines HL-60 (leukemia), A549 (lung adenocarcinoma), and BEL-7402 (hepatoma) with inhibition rates of 68.2%, 55.9%, and 31.7%, respectively, at 100 µM. It appears to have potential as an anticancer agent with selective activity.
Keywords: angucyclinone; epoxybenz[a]anthracene; marine Streptomyces; cytotoxicity

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Cite This Article

MDPI and ACS Style

Xie, Z.; Liu, B.; Wang, H.; Yang, S.; Zhang, H.; Wang, Y.; Ji, N.; Qin, S.; Laatsch, H. Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.. Mar. Drugs 2012, 10, 551-558.

AMA Style

Xie Z, Liu B, Wang H, Yang S, Zhang H, Wang Y, Ji N, Qin S, Laatsch H. Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.. Marine Drugs. 2012; 10(3):551-558.

Chicago/Turabian Style

Xie, Zeping; Liu, Bing; Wang, Hongpeng; Yang, Shengxiang; Zhang, Hongyu; Wang, Yipeng; Ji, Naiyun; Qin, Song; Laatsch, Hartmut. 2012. "Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.." Mar. Drugs 10, no. 3: 551-558.

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