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Mar. Drugs 2012, 10(3), 551-558; doi:10.3390/md10030551
Article

Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.

1,2,†
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1,†
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3
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4
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1,2
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1
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1
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1,*  and 3,*
1 Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China 2 Graduate University of Chinese Academy of Sciences, Beijing 100049, China 3 Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen D-37077, Germany 4 Chemical Biological Research Institute, College of Science, Northwest A & F University, Yangling 712100, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 9 January 2012 / Revised: 17 February 2012 / Accepted: 20 February 2012 / Published: 27 February 2012
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Abstract

Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data. The new angucyclinone derivative showed inhibitory activities against the human cell lines HL-60 (leukemia), A549 (lung adenocarcinoma), and BEL-7402 (hepatoma) with inhibition rates of 68.2%, 55.9%, and 31.7%, respectively, at 100 µM. It appears to have potential as an anticancer agent with selective activity.
Keywords: angucyclinone; epoxybenz[a]anthracene; marine Streptomyces; cytotoxicity angucyclinone; epoxybenz[a]anthracene; marine Streptomyces; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Xie, Z.; Liu, B.; Wang, H.; Yang, S.; Zhang, H.; Wang, Y.; Ji, N.; Qin, S.; Laatsch, H. Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.. Mar. Drugs 2012, 10, 551-558.

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