Mar. Drugs 2012, 10(3), 521-538; doi:10.3390/md10030521
Article

Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters

1 Department of Public Health Sciences, University of Hawaii at Manoa, East-West Road, Honolulu, HI 96822, USA 2 Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Institute of Traditional Chinese Medicine & Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China 3 Center for Marine Microbial Ecology and Diversity, University of Hawaii at Manoa, Honolulu, HI 96822, USA 4 Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, East-West Road, Honolulu, HI 96822, USA
* Authors to whom correspondence should be addressed.
Received: 25 December 2011; in revised form: 3 February 2012 / Accepted: 6 February 2012 / Published: 24 February 2012
(This article belongs to the Special Issue Marine Anti-infective Agents)
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Abstract: Marine environments are a rich source of significant bioactive compounds. The Hawaiian archipelago, located in the middle of the Pacific Ocean, hosts diverse microorganisms, including many endemic species. Thirty-eight microbial extracts from Hawaiian coastal waters were evaluated for their antiviral activity against four mammalian viruses including herpes simplex virus type one (HSV-1), vesicular stomatitis virus (VSV), vaccinia virus and poliovirus type one (poliovirus-1) using in vitro cell culture assay. Nine of the 38 microbial crude extracts showed antiviral potencies and three of these nine microbial extracts exhibited significant activity against the enveloped viruses. A secosteroid, 5α(H),17α(H),(20R)-beta-acetoxyergost-8(14)-ene was putatively identified and confirmed to be the active compound in these marine microbial extracts. These results warrant future in-depth tests on the isolation of these active elements in order to explore and validate their antiviral potential as important therapeutic remedies.
Keywords: marine extract; antiviral drug; antiviral activity; enveloped virus; secosteroids

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MDPI and ACS Style

Tong, J.; Trapido-Rosenthal, H.; Wang, J.; Wang, Y.; Li, Q.X.; Lu, Y. Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters. Mar. Drugs 2012, 10, 521-538.

AMA Style

Tong J, Trapido-Rosenthal H, Wang J, Wang Y, Li QX, Lu Y. Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters. Marine Drugs. 2012; 10(3):521-538.

Chicago/Turabian Style

Tong, Jing; Trapido-Rosenthal, Hank; Wang, Jun; Wang, Youwei; Li, Qing X.; Lu, Yuanan. 2012. "Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters." Mar. Drugs 10, no. 3: 521-538.

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