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Mar. Drugs 2012, 10(3), 521-538; doi:10.3390/md10030521
Article

Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters

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Received: 25 December 2011 / Revised: 3 February 2012 / Accepted: 6 February 2012 / Published: 24 February 2012
(This article belongs to the Special Issue Marine Anti-infective Agents)
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Abstract

Marine environments are a rich source of significant bioactive compounds. The Hawaiian archipelago, located in the middle of the Pacific Ocean, hosts diverse microorganisms, including many endemic species. Thirty-eight microbial extracts from Hawaiian coastal waters were evaluated for their antiviral activity against four mammalian viruses including herpes simplex virus type one (HSV-1), vesicular stomatitis virus (VSV), vaccinia virus and poliovirus type one (poliovirus-1) using in vitro cell culture assay. Nine of the 38 microbial crude extracts showed antiviral potencies and three of these nine microbial extracts exhibited significant activity against the enveloped viruses. A secosteroid, 5α(H),17α(H),(20R)-beta-acetoxyergost-8(14)-ene was putatively identified and confirmed to be the active compound in these marine microbial extracts. These results warrant future in-depth tests on the isolation of these active elements in order to explore and validate their antiviral potential as important therapeutic remedies.
Keywords: marine extract; antiviral drug; antiviral activity; enveloped virus; secosteroids marine extract; antiviral drug; antiviral activity; enveloped virus; secosteroids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tong, J.; Trapido-Rosenthal, H.; Wang, J.; Wang, Y.; Li, Q.X.; Lu, Y. Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters. Mar. Drugs 2012, 10, 521-538.

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