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Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters
Department of Public Health Sciences, University of Hawaii at Manoa, East-West Road, Honolulu, HI 96822, USA
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Institute of Traditional Chinese Medicine & Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
Center for Marine Microbial Ecology and Diversity, University of Hawaii at Manoa, Honolulu, HI 96822, USA
Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, East-West Road, Honolulu, HI 96822, USA
* Authors to whom correspondence should be addressed.
Received: 25 December 2011; in revised form: 3 February 2012 / Accepted: 6 February 2012 / Published: 24 February 2012
Abstract: Marine environments are a rich source of significant bioactive compounds. The Hawaiian archipelago, located in the middle of the Pacific Ocean, hosts diverse microorganisms, including many endemic species. Thirty-eight microbial extracts from Hawaiian coastal waters were evaluated for their antiviral activity against four mammalian viruses including herpes simplex virus type one (HSV-1), vesicular stomatitis virus (VSV), vaccinia virus and poliovirus type one (poliovirus-1) using in vitro cell culture assay. Nine of the 38 microbial crude extracts showed antiviral potencies and three of these nine microbial extracts exhibited significant activity against the enveloped viruses. A secosteroid, 5α(H),17α(H),(20R)-beta-acetoxyergost-8(14)-ene was putatively identified and confirmed to be the active compound in these marine microbial extracts. These results warrant future in-depth tests on the isolation of these active elements in order to explore and validate their antiviral potential as important therapeutic remedies.
Keywords: marine extract; antiviral drug; antiviral activity; enveloped virus; secosteroids
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MDPI and ACS Style
Tong, J.; Trapido-Rosenthal, H.; Wang, J.; Wang, Y.; Li, Q.X.; Lu, Y. Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters. Mar. Drugs 2012, 10, 521-538.
Tong J, Trapido-Rosenthal H, Wang J, Wang Y, Li QX, Lu Y. Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters. Marine Drugs. 2012; 10(3):521-538.
Tong, Jing; Trapido-Rosenthal, Hank; Wang, Jun; Wang, Youwei; Li, Qing X.; Lu, Yuanan. 2012. "Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters." Mar. Drugs 10, no. 3: 521-538.