Abstract: Marine environments are a rich source of significant bioactive compounds. The Hawaiian archipelago, located in the middle of the Pacific Ocean, hosts diverse microorganisms, including many endemic species. Thirty-eight microbial extracts from Hawaiian coastal waters were evaluated for their antiviral activity against four mammalian viruses including herpes simplex virus type one (HSV-1), vesicular stomatitis virus (VSV), vaccinia virus and poliovirus type one (poliovirus-1) using in vitro cell culture assay. Nine of the 38 microbial crude extracts showed antiviral potencies and three of these nine microbial extracts exhibited significant activity against the enveloped viruses. A secosteroid, 5α(H),17α(H),(20R)-beta-acetoxyergost-8(14)-ene was putatively identified and confirmed to be the active compound in these marine microbial extracts. These results warrant future in-depth tests on the isolation of these active elements in order to explore and validate their antiviral potential as important therapeutic remedies.
Keywords: marine extract; antiviral drug; antiviral activity; enveloped virus; secosteroids
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Tong, J.; Trapido-Rosenthal, H.; Wang, J.; Wang, Y.; Li, Q.X.; Lu, Y. Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters. Mar. Drugs 2012, 10, 521-538.
Tong J, Trapido-Rosenthal H, Wang J, Wang Y, Li QX, Lu Y. Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters. Marine Drugs. 2012; 10(3):521-538.
Tong, Jing; Trapido-Rosenthal, Hank; Wang, Jun; Wang, Youwei; Li, Qing X.; Lu, Yuanan. 2012. "Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters." Mar. Drugs 10, no. 3: 521-538.