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Mar. Drugs 2012, 10(2), 497-508; doi:10.3390/md10020497

A Sterol and Spiroditerpenoids from a Penicillium sp. Isolated from a Deep Sea Sediment Sample

1
Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China
2
Key Laboratory of Marine Biogenetic Resources, The Third Institute of Oceanography, The State Oceanic Administration, Xiamen 361005, China
*
Authors to whom correspondence should be addressed.
Received: 31 December 2011 / Revised: 1 February 2012 / Accepted: 13 February 2012 / Published: 20 February 2012
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Abstract

A new polyoxygenated sterol, sterolic acid (1), three new breviane spiroditerpenoids, breviones I–K (24), and the known breviones (58), were isolated from the crude extract of a Penicillium sp. obtained from a deep sea sediment sample that was collected at a depth of 5115 m. The structures of 14 were elucidated primarily by NMR experiments, and 1 was further confirmed by X-ray crystallography. The absolute configurations of 2 and 3 were deduced by comparison of their CD spectra with those of the model compounds. Compounds 2 and 5 showed significant cytotoxicity against MCF-7 cells, which is comparable to the positive control cisplatin.
Keywords: Penicillium sp.; deep sea sediment; sterol; spiroditerpenoids; cytotoxicity Penicillium sp.; deep sea sediment; sterol; spiroditerpenoids; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Li, Y.; Ye, D.; Shao, Z.; Cui, C.; Che, Y. A Sterol and Spiroditerpenoids from a Penicillium sp. Isolated from a Deep Sea Sediment Sample. Mar. Drugs 2012, 10, 497-508.

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