Next Article in Journal
Cyanobacterial Neurotoxin β-N-Methylamino-L-alanine (BMAA) in Shark Fins
Previous Article in Journal
Ovatoxin-a and Palytoxin Accumulation in Seafood in Relation to Ostreopsis cf. ovata Blooms on the French Mediterranean Coast
Mar. Drugs 2012, 10(2), 497-508; doi:10.3390/md10020497
Article

A Sterol and Spiroditerpenoids from a Penicillium sp. Isolated from a Deep Sea Sediment Sample

1
,
2
,
2
,
1,*  and 1,*
1 Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China 2 Key Laboratory of Marine Biogenetic Resources, The Third Institute of Oceanography, The State Oceanic Administration, Xiamen 361005, China
* Authors to whom correspondence should be addressed.
Received: 31 December 2011 / Revised: 1 February 2012 / Accepted: 13 February 2012 / Published: 20 February 2012
View Full-Text   |   Download PDF [369 KB, uploaded 24 February 2015]   |  

Abstract

A new polyoxygenated sterol, sterolic acid (1), three new breviane spiroditerpenoids, breviones I–K (24), and the known breviones (58), were isolated from the crude extract of a Penicillium sp. obtained from a deep sea sediment sample that was collected at a depth of 5115 m. The structures of 14 were elucidated primarily by NMR experiments, and 1 was further confirmed by X-ray crystallography. The absolute configurations of 2 and 3 were deduced by comparison of their CD spectra with those of the model compounds. Compounds 2 and 5 showed significant cytotoxicity against MCF-7 cells, which is comparable to the positive control cisplatin.
Keywords: Penicillium sp.; deep sea sediment; sterol; spiroditerpenoids; cytotoxicity Penicillium sp.; deep sea sediment; sterol; spiroditerpenoids; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Li, Y.; Ye, D.; Shao, Z.; Cui, C.; Che, Y. A Sterol and Spiroditerpenoids from a Penicillium sp. Isolated from a Deep Sea Sediment Sample. Mar. Drugs 2012, 10, 497-508.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert