Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)

doi:10.3390/md10020427

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Mar. Drugs 2012, 10(2), 427-438; doi:10.3390/md10020427

Article

Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)

Cheng-Hung Lee^1,2,3, Chia-Ying Kao^4,5, Shih-Yao Kao^4,5, Chih-Han Chang¹, Jui-Hsin Su^4,5,6, Tsong-Long Hwang⁷, Yueh-Hsiung Kuo⁸, Zhi-Hong Wen^6,* and Ping-Jyun Sung^4,5,6,*

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Received: 8 December 2011; in revised form: 6 February 2012 / Accepted: 9 February 2012 / Published: 15 February 2012

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract: A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to display a significant inhibitory effect on the release of elastase by human neutrophils.

Keywords: menelloide; germacrane; Menella; lobocrassin; cembrane; Lobophytum; elastase

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MDPI and ACS Style

Lee, C.-H.; Kao, C.-Y.; Kao, S.-Y.; Chang, C.-H.; Su, J.-H.; Hwang, T.-L.; Kuo, Y.-H.; Wen, Z.-H.; Sung, P.-J. Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea). Mar. Drugs 2012, 10, 427-438.

AMA Style

Lee C-H, Kao C-Y, Kao S-Y, Chang C-H, Su J-H, Hwang T-L, Kuo Y-H, Wen Z-H, Sung P-J. Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea). Marine Drugs. 2012; 10(2):427-438.

Chicago/Turabian Style

Lee, Cheng-Hung; Kao, Chia-Ying; Kao, Shih-Yao; Chang, Chih-Han; Su, Jui-Hsin; Hwang, Tsong-Long; Kuo, Yueh-Hsiung; Wen, Zhi-Hong; Sung, Ping-Jyun. 2012. "Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)." Mar. Drugs 10, no. 2: 427-438.

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