Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)

doi:10.3390/md10020427

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Mar. Drugs 2012, 10(2), 427-438; doi:10.3390/md10020427

Article

Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)

Cheng-Hung Lee^1,2,3, Chia-Ying Kao^4,5, Shih-Yao Kao^4,5, Chih-Han Chang¹, Jui-Hsin Su^4,5,6, Tsong-Long Hwang⁷, Yueh-Hsiung Kuo⁸, Zhi-Hong Wen^6,* and Ping-Jyun Sung^4,5,6,*

¹ Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan ² Department of Nutrition, HungKuang University, Taichung 433, Taiwan ³ Department of Orthopedics, Taichung Veterans General Hospital, Taichung 407, Taiwan ⁴ Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan ⁵ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan ⁶ Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan ⁷ Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan ⁸ School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources and Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 404, Taiwan

* Authors to whom correspondence should be addressed.

Received: 8 December 2011; in revised form: 6 February 2012 / Accepted: 9 February 2012 / Published: 15 February 2012

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Abstract: A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to display a significant inhibitory effect on the release of elastase by human neutrophils.

Keywords: menelloide; germacrane; Menella; lobocrassin; cembrane; Lobophytum; elastase

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Cite This Article

MDPI and ACS Style

Lee, C.-H.; Kao, C.-Y.; Kao, S.-Y.; Chang, C.-H.; Su, J.-H.; Hwang, T.-L.; Kuo, Y.-H.; Wen, Z.-H.; Sung, P.-J. Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea). Mar. Drugs 2012, 10, 427-438.

AMA Style

Lee C-H, Kao C-Y, Kao S-Y, Chang C-H, Su J-H, Hwang T-L, Kuo Y-H, Wen Z-H, Sung P-J. Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea). Marine Drugs. 2012; 10(2):427-438.

Chicago/Turabian Style

Lee, Cheng-Hung; Kao, Chia-Ying; Kao, Shih-Yao; Chang, Chih-Han; Su, Jui-Hsin; Hwang, Tsong-Long; Kuo, Yueh-Hsiung; Wen, Zhi-Hong; Sung, Ping-Jyun. 2012. "Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)." Mar. Drugs 10, no. 2: 427-438.

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