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Mar. Drugs 2012, 10(2), 427-438; doi:10.3390/md10020427
Article

Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)

1,2,3
, 4,5
, 4,5
, 1
, 4,5,6
, 7
, 8
, 6,*  and 4,5,6,*
1 Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan 2 Department of Nutrition, HungKuang University, Taichung 433, Taiwan 3 Department of Orthopedics, Taichung Veterans General Hospital, Taichung 407, Taiwan 4 Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 5 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 6 Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 7 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 8 School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources and Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 8 December 2011 / Revised: 6 February 2012 / Accepted: 9 February 2012 / Published: 15 February 2012
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Abstract

A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to display a significant inhibitory effect on the release of elastase by human neutrophils.
Keywords: menelloide; germacrane; Menella; lobocrassin; cembrane; Lobophytum; elastase menelloide; germacrane; Menella; lobocrassin; cembrane; Lobophytum; elastase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lee, C.-H.; Kao, C.-Y.; Kao, S.-Y.; Chang, C.-H.; Su, J.-H.; Hwang, T.-L.; Kuo, Y.-H.; Wen, Z.-H.; Sung, P.-J. Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea). Mar. Drugs 2012, 10, 427-438.

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