Mar. Drugs 2012, 10(2), 427-438; doi:10.3390/md10020427
Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)
Cheng-Hung Lee 1,2,3, Chia-Ying Kao 4,5, Shih-Yao Kao 4,5, Chih-Han Chang 1, Jui-Hsin Su 4,5,6, Tsong-Long Hwang 7
, Yueh-Hsiung Kuo 8, Zhi-Hong Wen 6,*
and Ping-Jyun Sung 4,5,6,*
, Yueh-Hsiung Kuo 8, Zhi-Hong Wen 6,*
and Ping-Jyun Sung 4,5,6,*
1
Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan
2
Department of Nutrition, HungKuang University, Taichung 433, Taiwan
3
Department of Orthopedics, Taichung Veterans General Hospital, Taichung 407, Taiwan
4
Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
5
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
6
Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
7
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
8
School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources and Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 404, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 8 December 2011 / Revised: 6 February 2012 / Accepted: 9 February 2012 / Published: 15 February 2012
Abstract
A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to display a significant inhibitory effect on the release of elastase by human neutrophils. View Full-TextKeywords:
menelloide; germacrane; Menella; lobocrassin; cembrane; Lobophytum; elastase
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Lee, C.-H.; Kao, C.-Y.; Kao, S.-Y.; Chang, C.-H.; Su, J.-H.; Hwang, T.-L.; Kuo, Y.-H.; Wen, Z.-H.; Sung, P.-J. Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea). Mar. Drugs 2012, 10, 427-438.
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