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Open AccessCommunication
Mar. Drugs 2012, 10(2), 417-426; doi:10.3390/md10020417

Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension

Research Center of Food Engineering, College of Chemistry and Engineering, Kunming University of Science and Technology, Kunming, Yunnan 650600, China
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Author to whom correspondence should be addressed.
Received: 25 December 2011 / Revised: 31 January 2012 / Accepted: 6 February 2012 / Published: 15 February 2012
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Abstract

Antihypertensive effect of long-term oral administration of jellyfish (Rhopilema esculentum) collagen peptides (JCP) on renovascular hypertension rats (RVHs) was evaluated. The systolic blood pressure and diastolic blood pressure of the RVHs were significantly reduced with administration of JCP (p < 0.05), compared with model control group. However, the arterial blood pressure of normal rats showed no significant changes during long-term oral treatment with high dose JCP (p > 0.05). Furthermore, effect of JCP on angiotensin II (Ang II) concentration of plasma had no significance (p > 0.05), but JCP significantly inhibited the Ang II concentration in RVHs’ kidney (p < 0.05). The kidney should be the target site of JCP.
Keywords: jellyfish; collagen peptide; blood pressure; angiotensin II; kidney jellyfish; collagen peptide; blood pressure; angiotensin II; kidney
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhuang, Y.; Sun, L.; Zhang, Y.; Liu, G. Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension. Mar. Drugs 2012, 10, 417-426.

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