Mar. Drugs 2012, 10(2), 439-450; doi:10.3390/md10020439
Article

Steroids from the Soft Coral Sinularia crassa

Chih-Hua Chao 1,2 email, Kuei-Ju Chou 3 email, Chiung-Yao Huang 3 email, Zhi-Hong Wen 3,4 email, Chi-Hsin Hsu 3,4 email, Yang-Chang Wu 5 email, Chang-Feng Dai 6 email and Jyh-Horng Sheu 3,4,* email
1 Chinese Medicinal Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan 2 China Medical University, Taichung, 40402, Taiwan 3 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 4 Asian Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 5 Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan 6 Institute of Oceanography, National Taiwan University, Taipei, 10617, Taiwan
* Author to whom correspondence should be addressed.
Received: 9 January 2012; in revised form: 7 February 2012 / Accepted: 9 February 2012 / Published: 16 February 2012
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Abstract: One new sterol, crassarosterol A (1), and four new steroidal glycosides, crassarosterosides A–D (2–5) were isolated from the Formosan soft coral Sinularia crassa. The absolute configuration of 1 was determined using the Mosher’s method. The absolute configurations for the sugar moieties of 2–5 were determined by HPLC analysis on the o-tolylthiocarbamates derived from the liberated sugar after acid hydrolysis. Compounds 2 and 4 could significantly inhibit the expression of pro-inflammatory iNOS protein at 10 µM. In contrast, 1–3 were found to stimulate the expression of COX-2 protein at this concentration. Steroids 1 and 4 also showed cytotoxicity toward the selected human liver cancer cells.
Keywords: Sinularia crassa; crassarosterosides A–D; crassarosterol A; anti-inflammatory activity; o-tolylthiocarbamate

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MDPI and ACS Style

Chao, C.-H.; Chou, K.-J.; Huang, C.-Y.; Wen, Z.-H.; Hsu, C.-H.; Wu, Y.-C.; Dai, C.-F.; Sheu, J.-H. Steroids from the Soft Coral Sinularia crassa . Mar. Drugs 2012, 10, 439-450.

AMA Style

Chao C-H, Chou K-J, Huang C-Y, Wen Z-H, Hsu C-H, Wu Y-C, Dai C-F, Sheu J-H. Steroids from the Soft Coral Sinularia crassa . Marine Drugs. 2012; 10(2):439-450.

Chicago/Turabian Style

Chao, Chih-Hua; Chou, Kuei-Ju; Huang, Chiung-Yao; Wen, Zhi-Hong; Hsu, Chi-Hsin; Wu, Yang-Chang; Dai, Chang-Feng; Sheu, Jyh-Horng. 2012. "Steroids from the Soft Coral Sinularia crassa ." Mar. Drugs 10, no. 2: 439-450.

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