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Mar. Drugs 2012, 10(2), 439-450; doi:10.3390/md10020439
Article

Steroids from the Soft Coral Sinularia crassa

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Received: 9 January 2012 / Revised: 7 February 2012 / Accepted: 9 February 2012 / Published: 16 February 2012
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Abstract

One new sterol, crassarosterol A (1), and four new steroidal glycosides, crassarosterosides A–D (25) were isolated from the Formosan soft coral Sinularia crassa. The absolute configuration of 1 was determined using the Mosher’s method. The absolute configurations for the sugar moieties of 25 were determined by HPLC analysis on the o-tolylthiocarbamates derived from the liberated sugar after acid hydrolysis. Compounds 2 and 4 could significantly inhibit the expression of pro-inflammatory iNOS protein at 10 µM. In contrast, 13 were found to stimulate the expression of COX-2 protein at this concentration. Steroids 1 and 4 also showed cytotoxicity toward the selected human liver cancer cells.
Keywords: Sinularia crassa; crassarosterosides A–D; crassarosterol A; anti-inflammatory activity; o-tolylthiocarbamate Sinularia crassa; crassarosterosides A–D; crassarosterol A; anti-inflammatory activity; o-tolylthiocarbamate
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chao, C.-H.; Chou, K.-J.; Huang, C.-Y.; Wen, Z.-H.; Hsu, C.-H.; Wu, Y.-C.; Dai, C.-F.; Sheu, J.-H. Steroids from the Soft Coral Sinularia crassa . Mar. Drugs 2012, 10, 439-450.

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