Mar. Drugs 2012, 10(11), 2509-2518; doi:10.3390/md10112509
Article

Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine

Marialuisa Menna 1,* email, Anna Aiello 1 email, Filomena D'Aniello 1 email, Ernesto Fattorusso 1,† email, Concetta Imperatore 1 email, Paolo Luciano 2 email and Rocco Vitalone 1 email
1 The NeaNat Group, Department of Chemistry of Natural Products, University of Naples “Federico II”, Via D. Montesano 49, Napoli 80131, Italy 2 C.S.I.A.S. (Interdepartmental Center of Instrumental Analysis), University of Naples “Federico II”, Via D. Montesano 49, Napoli 80131, Italy † Deceased on 7 July 2012.
* Author to whom correspondence should be addressed.
Received: 12 September 2012; in revised form: 26 October 2012 / Accepted: 30 October 2012 / Published: 9 November 2012
(This article belongs to the Special Issue Marine Secondary Metabolites)
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Abstract: An exhaustive exploration into the metabolic content of the Mediterranean sponge Axinella-polypoides resulted in the isolation of the new betaine 5 and the new cyclonucleoside 8. The structures of the new metabolites were elucidated by spectroscopic methods assisted by computational methods. The analysis also provided evidence that the sponge does not elaborate pyrrole-imidazole alkaloids (PIAs) but, interestingly, it was shown to contain two already known cyclodipeptides, compounds 9 (verpacamide A) and 10.
Keywords: natural products; sponges; Axinellidae; pyrrole-imidazole alkaloids; taxon-specificity

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MDPI and ACS Style

Menna, M.; Aiello, A.; D'Aniello, F.; Fattorusso, E.; Imperatore, C.; Luciano, P.; Vitalone, R. Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine. Mar. Drugs 2012, 10, 2509-2518.

AMA Style

Menna M, Aiello A, D'Aniello F, Fattorusso E, Imperatore C, Luciano P, Vitalone R. Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine. Marine Drugs. 2012; 10(11):2509-2518.

Chicago/Turabian Style

Menna, Marialuisa; Aiello, Anna; D'Aniello, Filomena; Fattorusso, Ernesto; Imperatore, Concetta; Luciano, Paolo; Vitalone, Rocco. 2012. "Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine." Mar. Drugs 10, no. 11: 2509-2518.

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