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Mar. Drugs 2012, 10(10), 2312-2321; doi:10.3390/md10102312

Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance

1
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA
2
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA
3
Department of Thoracic Surgery, Peking Union Medical College Hospital, Beijing 100730, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 28 August 2012 / Revised: 13 September 2012 / Accepted: 29 September 2012 / Published: 19 October 2012
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Abstract

The resistance of tumor cells to a broad range of anticancer agents continues to be a problem for the success of cancer chemotherapy. Multidrug resistance (MDR) is due in part to three drug transporter proteins: ABCB1/P-glycoprotein (P-gp), ABCC1/multidrug resistance protein 1 (MRP1) and ABCG2/breast cancer resistance protein (BCRP). These transporters are part of the ATP-binding cassette (ABC) superfamily, whose members function as ATP-dependent drug-efflux pumps. Their activity can be blocked by various drugs such as verapamil (calcium channel blocker) and cyclosporin A (immunosuppressive agent), etc. These compounds are called MDR modulators or reversals. This review highlights several marine natural products with reversal effect on multidrug resistance in cancer, including agosterol A, ecteinascidin 743, sipholane triterpenoids, bryostatin 1, and welwitindolinones. View Full-Text
Keywords: marine natural products; multidrug resistance; ABC transporters marine natural products; multidrug resistance; ABC transporters
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Abraham, I.; El Sayed, K.; Chen, Z.-S.; Guo, H. Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance. Mar. Drugs 2012, 10, 2312-2321.

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