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Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA
Department of Thoracic Surgery, Peking Union Medical College Hospital, Beijing 100730, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 28 August 2012; in revised form: 13 September 2012 / Accepted: 29 September 2012 / Published: 19 October 2012
Abstract: The resistance of tumor cells to a broad range of anticancer agents continues to be a problem for the success of cancer chemotherapy. Multidrug resistance (MDR) is due in part to three drug transporter proteins: ABCB1/P-glycoprotein (P-gp), ABCC1/multidrug resistance protein 1 (MRP1) and ABCG2/breast cancer resistance protein (BCRP). These transporters are part of the ATP-binding cassette (ABC) superfamily, whose members function as ATP-dependent drug-efflux pumps. Their activity can be blocked by various drugs such as verapamil (calcium channel blocker) and cyclosporin A (immunosuppressive agent), etc. These compounds are called MDR modulators or reversals. This review highlights several marine natural products with reversal effect on multidrug resistance in cancer, including agosterol A, ecteinascidin 743, sipholane triterpenoids, bryostatin 1, and welwitindolinones.
Keywords: marine natural products; multidrug resistance; ABC transporters
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Abraham, I.; El Sayed, K.; Chen, Z.-S.; Guo, H. Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance. Mar. Drugs 2012, 10, 2312-2321.
Abraham I, El Sayed K, Chen Z-S, Guo H. Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance. Marine Drugs. 2012; 10(10):2312-2321.
Abraham, Ioana; El Sayed, Khalid; Chen, Zhe-Sheng; Guo, Huiqin. 2012. "Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance." Mar. Drugs 10, no. 10: 2312-2321.