Next Article in Journal
Previous Article in Journal
Mar. Drugs 2012, 10(10), 2312-2321; doi:10.3390/md10102312
Review

Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance

1,†
, 2
, 1,*  and 3,†,*
Received: 28 August 2012; in revised form: 13 September 2012 / Accepted: 29 September 2012 / Published: 19 October 2012
View Full-Text   |   Download PDF [334 KB, uploaded 19 October 2012]   |   Browse Figure
Abstract: The resistance of tumor cells to a broad range of anticancer agents continues to be a problem for the success of cancer chemotherapy. Multidrug resistance (MDR) is due in part to three drug transporter proteins: ABCB1/P-glycoprotein (P-gp), ABCC1/multidrug resistance protein 1 (MRP1) and ABCG2/breast cancer resistance protein (BCRP). These transporters are part of the ATP-binding cassette (ABC) superfamily, whose members function as ATP-dependent drug-efflux pumps. Their activity can be blocked by various drugs such as verapamil (calcium channel blocker) and cyclosporin A (immunosuppressive agent), etc. These compounds are called MDR modulators or reversals. This review highlights several marine natural products with reversal effect on multidrug resistance in cancer, including agosterol A, ecteinascidin 743, sipholane triterpenoids, bryostatin 1, and welwitindolinones.
Keywords: marine natural products; multidrug resistance; ABC transporters marine natural products; multidrug resistance; ABC transporters
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Abraham, I.; El Sayed, K.; Chen, Z.-S.; Guo, H. Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance. Mar. Drugs 2012, 10, 2312-2321.

AMA Style

Abraham I, El Sayed K, Chen Z-S, Guo H. Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance. Marine Drugs. 2012; 10(10):2312-2321.

Chicago/Turabian Style

Abraham, Ioana; El Sayed, Khalid; Chen, Zhe-Sheng; Guo, Huiqin. 2012. "Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance." Mar. Drugs 10, no. 10: 2312-2321.



Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert