Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance
Abstract
:1. Introduction
Compounds | Source organism | Chemical class | Cell lines used | Refences |
---|---|---|---|---|
Agosterol A (AG-A) | Spongia sp. | polyhydroxylated sterol acetate | P-gp/MDR1-overexpressing (KB-C2) | [28,29,30] |
MRP1-overexpressing (KB-CV60) | [28,29,30] | |||
MRP1-transfected (KB/MRP) | [31] | |||
Ecteinascidin 743 (ET-743) | Ecteinascidia turbinate | tetrahydroiso-quinolone alkaloid | P-gp/MDR1-overexpressing (KB-8-5, KB-C2) | [32] |
Sipholenol A | Callyspongia siphonella | sipholane triterpenoids | P-gp/MDR1-overexpressing (KB-C2, KB-V1) | [33,34,35] |
Sipholenone E Sipholenol L Siphonellinol D | P-gp/MDR1-overexpressing (KB-C2) | [36] | ||
Bryostatin 1 | Bugula neritina | macrocyclic lactone | P-gp/MDR1-overexpressing (KB-C1, HeLa-MDR1-V185) | [37] |
N-Methylwelwitin-dolinone C isothiocyanate | Hapalosiphon welwitschii | alkaloid | P-gp/MDR1-overexpressing (SK-VLB-1, MCF-7/ADR) | [38] |
2. Agosterol A (AG-A)
3. Ecteinascidin 743 (ET-743)
4. Sipholane Triterpenoids
5. Bryostatin 1
6. Welwitindolinones
7. Conclusions
Acknowledgements
Conflict of Interest
References
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Abraham, I.; El Sayed, K.; Chen, Z.-S.; Guo, H. Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance. Mar. Drugs 2012, 10, 2312-2321. https://doi.org/10.3390/md10102312
Abraham I, El Sayed K, Chen Z-S, Guo H. Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance. Marine Drugs. 2012; 10(10):2312-2321. https://doi.org/10.3390/md10102312
Chicago/Turabian StyleAbraham, Ioana, Khalid El Sayed, Zhe-Sheng Chen, and Huiqin Guo. 2012. "Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance" Marine Drugs 10, no. 10: 2312-2321. https://doi.org/10.3390/md10102312