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Mar. Drugs 2012, 10(1), 119-130; doi:10.3390/md10010119
Article

Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate Crystallization

1,2
,
2
,
2
 and
1,*
1 Shanghai Key Laboratory of Functional Materials Chemistry, Research Center of Analysis and Testing, East China University of Science and Technology, Shanghai 200237, China 2 College of Food Science and Technology, Institutes of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China
* Author to whom correspondence should be addressed.
Received: 24 November 2011 / Revised: 2 January 2012 / Accepted: 5 January 2012 / Published: 16 January 2012
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Abstract

We investigated the effects of polysaccharides from the brown seaweed Sargassum graminifolium (Turn.) (SGP) on calcium oxalate crystallization, and determined its antioxidant activities. To examine the effects of SGP on calcium oxalate crystallization, we monitored nucleation and aggregation of calcium oxalate monohydrate crystals, using trisodium citrate as a positive control. We assessed antioxidant activities of SGP by determining its reducing power, its ability to scavenge superoxide radicals, and its activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The nucleation inhibition ratio of trisodium citrate and SGP was 58.5 and 69.2%, respectively, and crystal aggregation was inhibited by 71.4 and 76.8%, respectively. Increasing concentrations of SGP resulted in increased scavenging of superoxide anions and DPPH radicals (IC50 = 1.9 and 0.6 mg/mL, respectively). These results suggest that SGP could be a candidate for treating urinary stones because of its ability to inhibit calcium oxalate crystallization and its antioxidant properties.
Keywords: calcium oxalate crystallization; antioxidant; polysaccharide; Sargassum graminifolium calcium oxalate crystallization; antioxidant; polysaccharide; Sargassum graminifolium
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, C.-Y.; Wu, W.-H.; Wang, J.; Lan, M.-B. Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate Crystallization. Mar. Drugs 2012, 10, 119-130.

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