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Mar. Drugs 2012, 10(1), 131-139; doi:10.3390/md10010131
Article

Secondary Metabolites from an Algicolous Aspergillus versicolor Strain

1
, 1
, 1
, 2
 and 1,*
1 Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China 2 Natural Products Discovery Group, Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA
* Author to whom correspondence should be addressed.
Received: 29 November 2011 / Revised: 6 January 2012 / Accepted: 6 January 2012 / Published: 16 January 2012
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Abstract

Two new compounds, asperversin A (1) and 9ξ-O-2(2,3-dimethylbut-3-enyl)brevianamide Q (2), and nine known compounds, brevianamide K (3), brevianamide M (4), aversin (5), 6,8-di-O-methylnidurufin (6), 6,8-di-O-methylaverufin (7), 6-O-methylaverufin (8), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (9), ergosta-7,22-diene-3β,5α,6β-triol (10), and 6β-methoxyergosta-7,22-diene-3β,5α-diol (11), were obtained from the culture of Aspergillus versicolor, an endophytic fungus isolated from the marine brown alga Sargassum thunbergii. The structures of these compounds were established by spectroscopic techniques. Compounds 4, 7 and 8 exhibited antibacterial activities against Escherichia coli and Staphyloccocus aureus, and 7 also showed lethality against brine shrimp (Artemia salina) with an LC50 value of 0.5 μg/mL.
Keywords: Sargassum thunbergii; Aspergillus versicolor; asperversin A; 9ξ-O-2(2,3-dimethylbut-3-enyl)brevianamide Q Sargassum thunbergii; Aspergillus versicolor; asperversin A; 9ξ-O-2(2,3-dimethylbut-3-enyl)brevianamide Q
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Miao, F.-P.; Li, X.-D.; Liu, X.-H.; Cichewicz, R.H.; Ji, N.-Y. Secondary Metabolites from an Algicolous Aspergillus versicolor Strain. Mar. Drugs 2012, 10, 131-139.

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