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Secondary Metabolites from an Algicolous Aspergillus versicolor Strain
AbstractTwo new compounds, asperversin A (1) and 9ξ-O-2(2,3-dimethylbut-3-enyl)brevianamide Q (2), and nine known compounds, brevianamide K (3), brevianamide M (4), aversin (5), 6,8-di-O-methylnidurufin (6), 6,8-di-O-methylaverufin (7), 6-O-methylaverufin (8), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (9), ergosta-7,22-diene-3β,5α,6β-triol (10), and 6β-methoxyergosta-7,22-diene-3β,5α-diol (11), were obtained from the culture of Aspergillus versicolor, an endophytic fungus isolated from the marine brown alga Sargassum thunbergii. The structures of these compounds were established by spectroscopic techniques. Compounds 4, 7 and 8 exhibited antibacterial activities against Escherichia coli and Staphyloccocus aureus, and 7 also showed lethality against brine shrimp (Artemia salina) with an LC50 value of 0.5 μg/mL.
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Miao, F.-P.; Li, X.-D.; Liu, X.-H.; Cichewicz, R.H.; Ji, N.-Y. Secondary Metabolites from an Algicolous Aspergillus versicolor Strain. Mar. Drugs 2012, 10, 131-139.View more citation formats
Miao F-P, Li X-D, Liu X-H, Cichewicz RH, Ji N-Y. Secondary Metabolites from an Algicolous Aspergillus versicolor Strain. Marine Drugs. 2012; 10(1):131-139.Chicago/Turabian Style
Miao, Feng-Ping; Li, Xiao-Dong; Liu, Xiang-Hong; Cichewicz, Robert H.; Ji, Nai-Yun. 2012. "Secondary Metabolites from an Algicolous Aspergillus versicolor Strain." Mar. Drugs 10, no. 1: 131-139.