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A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp. F00120 Isolated from a Deep Sea Sediment Sample
Key Laboratory of Marine Bio-Resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
Biomedicine Research and Development Center of Jinan University, Guangzhou 510632, China
* Author to whom correspondence should be addressed.
Received: 28 November 2011; in revised form: 26 December 2011 / Accepted: 9 January 2012 / Published: 12 January 2012
Abstract: A new fungal strain, displaying strong toxic activity against brine shrimp larvae, was isolated from a deep sea sediment sample collected at a depth of 1300 m. The strain, designated as F00120, was identified as a member of the genus Penicillium on the basis of morphology and ITS sequence analysis. One new sesquiterpene quinone, named penicilliumin A (1), along with two known compounds ergosterol (2) and ergosterol peroxide (3), were isolated and purified from the cultures of F00120 by silica gel column, Sephadex LH-20 column, and preparative thin layer chromatography. Their structures were elucidated by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analysis as well as comparison with literature data. The new compound penicilliumin A inhibited in vitro proliferation of mouse melanoma (B16), human melanoma (A375), and human cervical carcinoma (Hela) cell lines moderately.
Keywords: Penicillium sp. F00120; sesquiterpene quinone; cytotoxic; deep sea sediment; penicilliumin A
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Lin, X.; Zhou, X.; Wang, F.; Liu, K.; Yang, B.; Yang, X.; Peng, Y.; Liu, J.; Ren, Z.; Liu, Y. A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp. F00120 Isolated from a Deep Sea Sediment Sample. Mar. Drugs 2012, 10, 106-115.
Lin X, Zhou X, Wang F, Liu K, Yang B, Yang X, Peng Y, Liu J, Ren Z, Liu Y. A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp. F00120 Isolated from a Deep Sea Sediment Sample. Marine Drugs. 2012; 10(1):106-115.
Lin, Xiuping; Zhou, Xuefeng; Wang, Fazuo; Liu, Kaisheng; Yang, Bin; Yang, Xianwen; Peng, Yan; Liu, Juan; Ren, Zhe; Liu, Yonghong. 2012. "A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp. F00120 Isolated from a Deep Sea Sediment Sample." Mar. Drugs 10, no. 1: 106-115.