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Pharmaceuticals 2015, 8(4), 836-847; doi:10.3390/ph8040836

The Type I IFN-Induced miRNA, miR-21

1
Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 19 S. Manassas St., Memphis, TN 38163, USA
2
Center for Cancer Research, University of Tennessee Health Science Center, 19 S. Manassas St., Memphis, TN 38163, USA
3
Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Howard A. Young
Received: 29 September 2015 / Revised: 10 November 2015 / Accepted: 20 November 2015 / Published: 25 November 2015
(This article belongs to the Special Issue Interferons 2015)
View Full-Text   |   Download PDF [794 KB, uploaded 25 November 2015]   |  

Abstract

The interferon (IFN) family of cytokines not only has antiviral properties at various steps in the viral replication cycle, but also anticancer activity through multiple pathways that include inhibiting cell proliferation, regulating cellular responses to inducers of apoptosis and modulating angiogenesis and the immune system. IFNs are known to induce their biological activity through the induction of protein encoding IFN-stimulated genes. However, recent studies have established that IFNs also induce the expression of microRNAs (miRNAs), which are small endogenous non-coding RNAs that suppress gene expression at the post-transcriptional level. MiRNAs play critical roles in tumorigenesis and have been implicated to act as either oncogenes or tumor suppressors in various human cancers. Therefore, IFN-induced miRNAs play an important role, not only in the host response to innate immune response to cancer, but also in the tumorigenic process itself. Furthermore, IFN-induced miRNAs may participate in and/or orchestrate antiviral defense in certain viral infections. In this review, we describe our recent studies on the induction of miR-21 by type I IFN, the role of the STAT3 and NFκB signaling pathways in IFN-induced miR-21 expression, the role of miR-21 in different cancers and the role of miR-21 in regulating the antiviral response. View Full-Text
Keywords: IFN; miRNAs; cancer; antiviral IFN; miRNAs; cancer; antiviral
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yang, C.H.; Li, K.; Pfeffer, S.R.; Pfeffer, L.M. The Type I IFN-Induced miRNA, miR-21. Pharmaceuticals 2015, 8, 836-847.

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